Details of Drug

Drug General Information (ID: D0845)
Drug Name	Irinotecan
Drug Type	Small molecule
Drug Synonymous	Biotecan; Camptosar; Irinotecanum; IRINOTECAN HYDROCHLORIDE Trihydrate; Irinotecan Hcl; Irinotecan hydrochloride; CP0; Biotecan (TN); Campto (TN); Camptosar (TN); Irinotecan (INN); Irinotecan [INN:BAN]; Irinotecanum [INN-Latin]; IRINOTECAN, CPT-11; Camptosar, Campto, CPT-11, Irinotecan; (+)-Irinotecan; (4S)-4,11-DIETHYL-4-HYDROXY-3,14-DIOXO-3,4,12,14-TETRAHYDRO-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL 1,4'-BIPIPERIDINE-1'-CARBOXYLATE; (4S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-4,12-dihydro-1H-pyrano[3,4-f]quinolino[2,3-a]indolizin-9-yl 4-piperidylpiperidinecarboxylate; Irinotecan (TOPO1 inhibitor); Onivyde Click to Show/Hide
Disease Class	2B91: Colorectal cancer
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C33H38N4O6
InChI	1S/C33H38N4O6/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3/t33-/m0/s1
InChIKey	UWKQSNNFCGGAFS-XIFFEERXSA-N
Canonical SMILES	CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7
External Link
	Pubchem ID	60838
	CAS Number	97682-44-5
	CHEBI ID	80630
	TTD ID	D07HOB
	VARIDT ID	DR00112

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM006 Altered intestinal mucosa BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM019 UGT inhibition BM022 CYP450 enzyme induction BM023 UGT induction BM024 Competitive inhibition of metabolic enzyme BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM047 Additive thrombogenic effects BM095 Antagonize the effect of neuromuscular blocking agents BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Irinotecan
Affected gastrointestinal absorption
	Altered intestinal mucosa					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0573		Enoxacin	C15H17FN4O3	3229	Minor		Inter Info	[151]
D0340		Cinoxacin	C12H10N2O5	2762	Minor		Inter Info	[151]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Minor		Inter Info	[151]
D0712		Gatifloxacin	C19H22FN3O4	5379	Minor		Inter Info	[151]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Minor		Inter Info	[151]
D0919		Levofloxacin	C18H20FN3O4	149096	Minor		Inter Info	[151]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Minor		Inter Info	[151]
D1102		Nalidixic acid	C12H12N2O3	4421	Minor		Inter Info	[151]
D1155		Norfloxacin	C16H18FN3O3	4539	Minor		Inter Info	[151]
D1165		Ofloxacin	C18H20FN3O4	4583	Minor		Inter Info	[151]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Minor		Inter Info	[151]
D1092		Moxifloxacin	C21H24FN3O4	152946	Minor		Inter Info	[151]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Minor		Inter Info	[151]
Affected cellular transport
	Transporter inhibition					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[9], [87], [88]
D0155		Bempedoic acid	C19H36O5	10472693	Moderate		Inter Info	[91], [92]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[9], [96], [70]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[100]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[102]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[106], [7], [8], [107], [108]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[8], [109]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[9], [110]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[112]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[8], [9], [115]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[9], [116]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[117]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[9]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[133]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 79
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[8], [9], [12], [13]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[7], [8], [9], [11], [12], [26], [13], [27]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[7], [8], [9], [11], [12], [35], [13], [36]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[7], [8], [9], [11], [12], [35], [13], [36]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[76], [77], [78], [79], [80], [81]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[86]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[8], [9], [10]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[76], [77], [78], [79], [80], [81]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[8], [9], [10]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[111]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[118]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[8], [9], [10]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[8], [9], [10]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[147], [148]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0345		Citalopram	C20H21FN2O	2771	Minor		Inter Info	[150]
	UGT inhibition					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0715		Gemfibrozil	C15H22O3	3463	Major		Inter Info	[8], [9], [12], [13]
D1528		Tafamidis	C14H7Cl2NO3	11001318	Moderate		Inter Info	[9], [138], [139]
	CYP450 enzyme induction					Drug Num: 53
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[14], [15], [16], [17], [18], [19], [12], [13], [20], [21], [22]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[14], [15], [16], [17], [18], [19], [12], [13], [20], [21], [22]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[14], [15], [16], [17], [18], [19], [12], [13], [20], [21], [22]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[14], [15], [16], [17], [18], [19], [12], [13], [20], [21], [22]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[17], [12], [20]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[14], [15], [16], [17], [18], [19], [12], [13], [20], [21], [22]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[14], [15], [16], [17], [18], [19], [12], [13], [20], [21], [22]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[17], [12], [20]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[14], [15], [16], [17], [18], [19], [12], [13], [20], [21], [22]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[46], [47], [48]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[14], [15], [16], [17], [18], [19], [12], [13], [20], [21], [22]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[14], [15], [16], [17], [18], [19], [12], [13], [20], [21], [22]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[14], [15], [16], [17], [18], [19], [12], [13], [20], [21], [22]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[9], [101]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[8], [105]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[46], [15], [18]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[9], [130]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[46], [15], [18]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[9], [140]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[46], [15], [18]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[14], [46], [15], [16], [17], [47], [48], [18], [19], [12], [13], [20], [21], [72], [22]
	Competitive inhibition of metabolic enzyme					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[134], [135]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[134], [135]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[134], [135]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 38
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[9], [23]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[8], [9], [31]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[34]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[37], [38]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[9], [39]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[8], [43]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[37], [38]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[66]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[67]
D1111		Natalizumab	NA	NA	Major		Inter Info	[68]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[44], [69], [70]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[71]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[73], [74], [75]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[82]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[8], [9]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[73], [74], [75]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[103]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[104]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[104]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[104]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[119]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[120]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[9], [121]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[122]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[131]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[73], [74], [75]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[9], [132]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[136]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[8], [9], [137]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[141]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[142]
D1855		Palifermin	NA	NA	Moderate		Inter Info	[144]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[8], [9], [149]
	Additive myelosuppressive effects					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[9], [24], [25]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[8], [32], [33]
D1435		Sacituzumab govitecan	C76H104N12O24S	91668186	Major		Inter Info	[41]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[42]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[8], [9], [113], [114]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[8], [9], [113], [114]
	Additive thrombogenic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1220		Panitumumab	NA	NA	Major		Inter Info	[8], [9], [40]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[12]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[12]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[12]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[12]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[12]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[12]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[12]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[12]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[12]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[12]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[12]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[12]
D0975		Magnesium sulfate	MgO4S	24083	Moderate		Inter Info	[12]
Pharmacodynamic antagonistic effects
	Antagonize the effect of neuromuscular blocking agents					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0343		Cisatracurium	C53H72N2O12+2	62887	Minor		Inter Info	[12]
D0122		Atracurium	C53H72N2O12+2	47319	Minor		Inter Info	[12]
D0522		Doxacurium	C56H78N2O16+2	60169	Minor		Inter Info	[12]
D1047		Metocurine	C40H48N2O6+2	21233	Minor		Inter Info	[12]
D1080		Mivacurium	C58H80N2O14+2	5281042	Minor		Inter Info	[12]
D1219		Pancuronium	C35H60N2O4+2	441289	Minor		Inter Info	[12]
D1295		Pipecuronium	C35H62N4O4+2	50192	Minor		Inter Info	[12]
D1384		Rapacuronium	C37H61N2O4+	5311399	Minor		Inter Info	[12]
D1659		Tubocurarine	C37H41N2O6+	6000	Minor		Inter Info	[12]
D1684		Vecuronium	C34H57N2O4+	39765	Minor		Inter Info	[12]
D1420		Rocuronium	C32H53N2O4+	441290	Minor		Inter Info	[12]
D1510		Succinylcholine	C14H30N2O4+2	5314	Minor		Inter Info	[152], [12]
	Antagonize the effect of vaccine/toxoid					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[28], [29], [30]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[28], [29], [30]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[28], [29], [30]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[28], [29], [30]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[28], [29], [30]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[44], [8], [45]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[49]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[28], [29], [30]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[28], [29], [30]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[28], [29], [30]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[44], [89], [90]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[44], [89], [90]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[44], [89], [90]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[44], [89], [90]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[44], [89], [90]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[44], [89], [90]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[44], [89], [90]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[44], [89], [90]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[123], [44], [8], [124], [125], [126], [89], [127], [128], [129], [90]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[44], [89], [90]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[44], [89], [90]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[44], [89], [90]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[143]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[93], [94], [95]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[93], [94], [95]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[97], [98], [99]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[97], [98], [99]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[97], [98], [99]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[97], [98], [99]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[83], [84], [85]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[145], [146]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[83], [84], [85]

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127	Product Information. Influenza Virus Vaccine, H5N1, Inactivated (influenza virus vaccine, H5N1, inactivated). GlaxoSmithKline, Research Triangle Park, NC.
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134	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
135	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
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147	Product Information. Nexavar (sorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
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