Drug General Information (ID: DDIR4ATKVE)
Drug Name			Irinotecan		Drug Info		Frangula purshiana bark		Drug Info
Drug Type		Small molecule				Natural product
Therapeutic Class		Antineoplastics				Herbal Products

Mechanism of Irinotecan-Frangula purshiana bark Interaction (Severity Level: Moderate)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Irinotecan				Frangula purshiana bark
Mechanism		Diarrhea				Laxative
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Irinotecan and Frangula purshiana bark

Recommended Action
Management		In patients requiring laxatives for constipation associated with narcotic administration, the standard regimen may be continued under supervision of the clinician. However, patients should be advised to inform their physician of any changes in their bowel habit so that dosage adjustments or discontinuation of laxatives may be done promptly.

References
1	Product Information. Camptosar (irinotecan). Pharmacia and Upjohn, Kalamazoo, MI.