Drug General Information (ID: DDIG3H782O)
Drug Name			Magnesium sulfate		Drug Info		Irinotecan		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Antineoplastics
Structure

Mechanism of Magnesium sulfate-Irinotecan Interaction (Severity Level: Moderate)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Magnesium sulfate				Irinotecan
Mechanism		Laxative				Diarrhea
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Magnesium sulfate and Irinotecan

Recommended Action
Management		In patients requiring laxatives for constipation associated with narcotic administration, the standard regimen may be continued under supervision of the clinician. However, patients should be advised to inform their physician of any changes in their bowel habit so that dosage adjustments or discontinuation of laxatives may be done promptly.

References
1	Product Information. Camptosar (irinotecan). Pharmacia and Upjohn, Kalamazoo, MI.