Details of Drug

Drug General Information (ID: D0975)
Drug Name	Magnesium sulfate
Drug Type	Small molecule
Drug Synonymous	Magnesiumsulfat; Bitter salt; Epsom salt; Hair salt; Heptahydrate Magnesium Sulfate; Kieserite [as monohydrate]; Magnesium Sulfate In Plastic Container; Magnesium Sulphate Hydrate; Magnesium bisulfate; Magnesium hydrogensulphate; Magnesium sulfate anhydrous; Magnesium sulfate dried; Magnesium sulfate hexahydrate; Magnesium sulfate solution; Magnesium sulphate; Sal Angalis; Sal De sedlitz; Sal amarum; Sal anglicum; Sal catharticum; Sal seidlitense; Salts of england; Sulfuric acid magnesium salt; Tomix OT; MgSO4; Epsom Sa (TN); Magnesium Sulfate, Heptahydrate; Magnesium sulfate in dextrose 5% in plastic container; Magnesium(II) sulfate; OT-S; Sel d'angleterre; Sulfate, Magnesium; Sulfuric acid magnesium salt (VAN); Sulfuric acid, magnesium salt; Magnesium sulfate (1:1); Magnesium(2+) ion sulfate; OT-S (drying agent); SDA 15-062-07; Sulfuric acid magnesium salt (1:1); Sulfuric acid, C10-16 alkyl ester, magnesium salt; Sulfuric acid, magnesium salt (1:1); Sulfuric acid, mono-C10-16-alkyl esters, magnesium salts; (C10-C16) Alkylalcohol sulfuric acid, magnesium salt Click to Show/Hide
Disease Class	MG31: Acute pain
Therapeutic Class	Analgesics
Structure
Structure	3D Structure		2D Structure
Formula	MgO4S
InChI	1S/Mg.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2
InChIKey	CSNNHWWHGAXBCP-UHFFFAOYSA-L
Canonical SMILES	[O-]S(=O)(=O)[O-].[Mg+2]
External Link
	Pubchem ID	24083
	CAS Number	7487-88-9
	CHEBI ID	32599
	TTD ID	D02LDN

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM003 Complex formation BM014 Interference of cell/tissue uptake BM042 Additive hypotensive effects BM045 Additive neuromuscular blocking effects BM059 Increased risk of hypermagnesemia BM065 Increased risk of hypokalemia BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Magnesium sulfate
Affected gastrointestinal absorption
	Complex formation					Drug Num: 34
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0181		Bictegravir	C21H18F3N3O5	90311989	Major		Inter Info	[3], [7], [8]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Major		Inter Info	[9]
D0034		Alendronic acid	C4H13NO7P2	2088	Moderate		Inter Info	[11], [12], [13]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D0441		Demeclocycline	C21H21ClN2O8	54680690	Moderate		Inter Info	[60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [47], [70], [57]
D0530		Doxycycline	C22H24N2O8	54671203	Moderate		Inter Info	[60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [47], [70], [57]
D0573		Enoxacin	C15H17FN4O3	3229	Moderate		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D0144		Baloxavir marboxil	C27H23F2N3O7S	124081896	Moderate		Inter Info	[71]
D0340		Cinoxacin	C12H10N2O5	2762	Moderate		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D0433		Deferiprone	C7H9NO2	2972	Moderate		Inter Info	[72]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Moderate		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[7], [73]
D0623		Etidronic acid	C2H8O7P2	3305	Moderate		Inter Info	[12], [74], [13]
D0712		Gatifloxacin	C19H22FN3O4	5379	Moderate		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D0783		Ibandronate	C9H23NO7P2	60852	Moderate		Inter Info	[77], [78], [11], [12], [79], [13]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D1070		Minocycline	C23H27N3O7	54675783	Moderate		Inter Info	[60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [47], [70], [57]
D1102		Nalidixic acid	C12H12N2O3	4421	Moderate		Inter Info	[81]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D1175		Omadacycline	C29H40N4O7	54697325	Moderate		Inter Info	[60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [47], [70], [57]
D1245		Penicillamine	C5H11NO2S	5852	Moderate		Inter Info	[82], [83], [84], [85], [86], [87], [88], [47]
D1377		Raltegravir	C20H21FN6O5	54671008	Moderate		Inter Info	[2], [3], [7], [89], [90], [91]
D1412		Risedronic acid	C7H11NO7P2	5245	Moderate		Inter Info	[11], [12], [13]
D1445		Sarecycline	C24H29N3O8	54681908	Moderate		Inter Info	[60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [47], [70], [57]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Moderate		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D1564		Tetracycline	C22H24N2O8	54675776	Moderate		Inter Info	[60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [47], [70], [57]
D1584		Tiludronic acid	C7H9ClO6P2S	60937	Moderate		Inter Info	[12], [74], [13]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Moderate		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D1092		Moxifloxacin	C21H24FN3O4	152946	Moderate		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D1209		Oxytetracycline	C22H24N2O9	54675779	Moderate		Inter Info	[60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [47], [70], [57]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0670		Fludeoxyglucose (18F)	C6H11FO5	170049	Moderate		Inter Info	[3], [75], [76]
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[14], [15], [2], [7], [16], [17], [18]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[14], [15], [2], [7], [16], [17], [18]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[14], [15], [2], [7], [16], [17], [18]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[14], [15], [2], [7], [16], [17], [18]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[14], [15], [2], [7], [16], [17], [18]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[14], [15], [2], [7], [16], [17], [18]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[14], [15], [2], [7], [16], [17], [18]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[14], [15], [2], [7], [16], [17], [18]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[14], [15], [2], [7], [16], [17], [18]
	Additive neuromuscular blocking effects					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0056		Amikacin	C22H43N5O13	37768	Major		Inter Info	[1], [2], [3], [4], [5]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Major		Inter Info	[6], [2], [3]
D0718		Gentamicin	C21H43N5O7	3467	Major		Inter Info	[1], [2], [3], [4], [5]
D0876		Kanamycin	C18H36N4O11	6032	Major		Inter Info	[1], [2], [3], [4], [5]
D1120		Neomycin	C23H46N6O13	8378	Major		Inter Info	[1], [2], [3], [4], [5]
D1126		Netilmicin	C21H41N5O7	441306	Major		Inter Info	[1], [2], [3], [4], [5]
D1304		Plazomicin	C25H48N6O10	42613186	Major		Inter Info	[1], [2], [3], [4], [5]
D1507		Streptomycin	C21H39N7O12	19649	Major		Inter Info	[1], [2], [3], [4], [5]
D1597		Tobramycin	C18H37N5O9	36294	Major		Inter Info	[1], [2], [3], [4], [5]
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[58], [59]
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[58], [59]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[58], [59]
D1219		Pancuronium	C35H60N2O4+2	441289	Moderate		Inter Info	[58], [59]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[58], [59]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[58], [59]
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[58], [59]
	Increased risk of hypermagnesemia					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0233		Calcifediol	C27H44O2	5283731	Moderate		Inter Info	[22], [23], [24], [25]
D0234		Calcitriol	C27H44O3	5280453	Moderate		Inter Info	[22], [23], [24], [25]
D0328		Cholecalciferol	C27H44O	5280795	Moderate		Inter Info	[22], [23], [24], [25]
D0591		Ergocalciferol	C28H44O	5280793	Moderate		Inter Info	[22], [23], [24], [25]
D0495		Dihydrotachysterol	C28H46O	5311071	Moderate		Inter Info	[22], [23], [24], [25]
D0527		Doxercalciferol	C28H44O2	5281107	Moderate		Inter Info	[22], [23], [24], [25]
D0968		Magnesium carbonate	CMgO3	11029	Moderate		Inter Info	[7]
D0969		Magnesium chloride	Cl2H12MgO6	643991	Moderate		Inter Info	[7]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[7]
D0971		Magnesium gluconate	C12H22MgO14	11418570	Moderate		Inter Info	[7]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[7]
D0974		Magnesium oxide	MgO	14792	Moderate		Inter Info	[7]
D1226		Paricalcitol	C27H44O3	5281104	Moderate		Inter Info	[22], [23], [24], [25]
	Increased risk of hypokalemia					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[19], [20], [21]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[19], [20], [21]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[19], [20], [21]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[19], [20], [21]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[19], [20], [21]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[19], [20], [21]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[19], [20], [21]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[19], [20], [21]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[19], [20], [21]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[19], [20], [21]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[19], [20], [21]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Moderate		Inter Info	[19], [20], [21]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[80]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[80]
D0929		Linaclotide	C59H79N15O21S6	16158208	Minor		Inter Info	[92], [93]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0590		Erdafitinib	C25H30N6O2	67462786	Major		Inter Info	[10]

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