Drug General Information (ID: DDIFINMGAW)
Drug Name			Amikacin (liposome)		Drug Info		Magnesium sulfate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Analgesics
Structure

Mechanism of Amikacin (liposome)-Magnesium sulfate Interaction (Severity Level: Major)
Additive neuromuscular blocking effects Click to Show/Hide Mechanism Graph
Drug Name		Amikacin (liposome)				Magnesium sulfate
Mechanism		Neuromuscular blocking effects Aminoglycosides				Neuromuscular blocking effects Magnesium
Key Mechanism Factor 1
		Factor Name		Neuromuscular blocking effects
		Factor Description		Neuromuscular blocking agents cause paralysis of affected skeletal muscles by blocking postsynaptic acetylcholine (Nm) receptors, thereby blocking neuromuscular signaling at the neuromuscular junction. Neuromuscular blocking agents can cause the following side effects: muscle paralysis, jaw stiffness, and shortness of breath. Concomitant use of drugs with neuromuscular blocking activity may result in severe and/or prolonged respiratory depression.
Mechanism Description		Additive neuromuscular blocking effects by the combination of Amikacin (liposome) and Magnesium sulfate

Recommended Action
Management		Close monitoring for increased or prolonged neuromuscular blockade and respiratory depression is recommended during concomitant use, especially in patients with renal impairment and/or with elevated magnesium levels. It may be advisable to avoid administration of aminoglycosides in infants with hypermagnesemia

References
1	Brunton LL, Lazo JS, Parker KL, eds. "Goodman &amp Gilman's the Pharmacological Basis of Therapeutics. 11th ed." New York, NY: McGraw-Hill (2006):.
2	Canadian Pharmacists Association.
3	Cerner Multum, Inc. "Australian Product Information.".