Drug General Information (ID: DDIDSVFYW7)
Drug Name			Magnesium sulfate		Drug Info		Dolutegravir		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Antiviral Agents
Structure

Mechanism of Magnesium sulfate-Dolutegravir Interaction (Severity Level: Major)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Magnesium sulfate				Dolutegravir
Mechanism		Polyvalent cations				Binds to polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Magnesium sulfate due to formation of complexes caused by Dolutegravir

Recommended Action
Management		Dolutegravir should be administered 2 hours before or 6 hours after medications containing polyvalent cations such as antacids, laxatives, or mineral supplements.

References
1	Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.