Drug General Information (ID: DDI3OJK6WT)
Drug Name			Magnesium sulfate		Drug Info		Nalidixic acid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Antibiotics
Structure

Mechanism of Magnesium sulfate-Nalidixic acid Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Magnesium sulfate				Nalidixic acid
Mechanism		Polyvalent cations				Binds to polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Magnesium sulfate due to formation of complexes caused by Nalidixic acid

Recommended Action
Management		When coadministration cannot be avoided, nalidixic acid should be dosed at least 2 hours before or 2 hours after polyvalent cation-containing products to minimize the potential for interaction.

References
1	Product Information. NegGram (nalidixic acid). Sanofi Winthrop Pharmaceuticals, New York, NY.