Drug General Information (ID: DDIIR02VLM)
Drug Name			Magnesium sulfate		Drug Info		Magnesium oxide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Minerals And Electrolytes
Structure

Mechanism of Magnesium sulfate-Magnesium oxide Interaction (Severity Level: Moderate)
Increased risk of hypermagnesemia Click to Show/Hide Mechanism Graph
Drug Name		Magnesium sulfate				Magnesium oxide
Mechanism		Hypermagnesemia				Hypermagnesemia
Key Mechanism Factor 1
		Factor Name		Hypermagnesemia
		Factor Description		Hypomagnesemia is a condition that occurs when you have too much magnesium in your body. Symptoms of hypomagnesemia include: nausea, vomiting, neurological damage, abnormally low blood pressure (hypotension), flushing, and headaches.
Mechanism Description		Increased risk of hypermagnesemia by the combination of Magnesium sulfate and Magnesium oxide

Recommended Action
Management		Clinical and laboratory monitoring for signs of hypermagnesemia and magnesium toxicity is advisable, especially in high-risk patients (e.g., elderly or renally impaired patients).

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".