Details of Drug-Drug Interaction
| Drug General Information (ID: DDIF2ONYK4) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Irinotecan | Drug Info | Tubocurarine | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antineoplastics | Neuromuscular Blocking Agents | |||||||
| Structure | |||||||||
| Mechanism of Irinotecan-Tubocurarine Interaction (Severity Level: Minor) | |||||||||
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| Antagonize the effect of neuromuscular blocking agents Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Irinotecan | Tubocurarine | |||||||
| Mechanism | Attenuates neuromuscular blockade |
Neuromuscular blocking agent Neuronal acetylcholine receptor Antagonist |
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| Key Mechanism Factor 1 | |||||||||
| Factor Name | Neuronal acetylcholine receptor | Structure Sequence | |||||||
| Protein Family | Ligand-gated ion channel (TC 1.A.9) family | ||||||||
| Protein Function |
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Click to Show/Hide
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| Mechanism Description |
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| References | |||||||||||||||||||
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| 1 | Product Information. Camptosar (irinotecan). Pharmacia and Upjohn, Kalamazoo, MI. | ||||||||||||||||||