Drug General Information (ID: DDI6CGFLD4)
Drug Name			Zidovudine		Drug Info		Stavudine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anti-Hiv Agents				Anti-Hiv Agents
Structure

Mechanism of Zidovudine-Stavudine Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Zidovudine				Stavudine
Mechanism		Intracellular phosphorylation inhibitor				Prodrug activated by intracellular phosphorylation
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Zidovudine when combined with Stavudine

Recommended Action
Management		The manufacturer recommends against concurrent use.

References
1	Product Information. Retrovir (zidovudine). Glaxo Wellcome, Research Triangle Park, NC.
2	Hoggard PG, Kewn S, Barry MG, Khoo SH, Back DJ. Effects of drugs on 2',3'-dideoxy-2',3'-didehydrothymidine phosphorylation in vitro. Antimicrob Agents Chemother. 1997 Jun;41(6):1231-6.
3	Havlir DV, Tierney C, Friedland GH, Pollard RB, Smeaton L, Sommadossi JP, Fox L, Kessler H, Fife KH, Richman DD "In vivo antagonism with zidovudine plus stavudine combination therapy." J Infec Dis 182 (2000): 321-5