Drug General Information (ID: DDINHE6RFP)
  Drug Name Zidovudine Drug Info Clarithromycin Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Anti-Hiv Agents Antibiotics
  Structure

 Mechanism of Zidovudine-Clarithromycin Interaction (Severity Level: Minor)
     Altered gastrointestinal dynamics Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Zidovudine Clarithromycin
      Mechanism Absorption affected by delayed gastric emptying Delayed gastric emptying
      Key Mechanism Factor 1
Factor Name Gastrointestinal Motility
Factor Description Gastrointestinal motility is an important factor in determining the absorption of orally administered drugs, and it controls the residence time of the drug in the digestive tract.
      Mechanism Description
  • Altered absorption of Zidovudine due to GI dynamics variation caused by Clarithromycin 

References
1 Brockmeyer NH, Tillmann I, Mertins L, Barthel B, Goos M. Pharmacokinetic interaction of fluconazole and zidovudine in HIV-positive patients. Eur J Med Res. 1997;2(9):377-383. [PMID: 9300934]
2 Vance E, Watsonbitar M, Gustavson L, Kazanjian P "Pharmacokinetics of clarithromycin and zidovudine in patients with AIDS." Antimicrob Agents Chemother 39 (1995): 1355-60. [PMID: 7574530]