Drug General Information (ID: DDITLHC83E)
Drug Name			Ketorolac		Drug Info		Probenecid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Uricosuric Agents
Structure

Mechanism of Ketorolac-Probenecid Interaction (Severity Level: Major)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Ketorolac				Probenecid
Mechanism		Ketorolac				Reduce the renal clearance of ketorolac
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Ketorolac and Probenecid

Recommended Action
Management		The manufacturer considers the concurrent use of probenecid and ketorolac contraindicated.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Toradol (ketorolac). Roche Laboratories, Nutley, NJ.