Drug General Information (ID: DDIVWKLM5R)
Drug Name			Dyphylline		Drug Info		Probenecid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Bronchodilators				Uricosuric Agents
Structure

Mechanism of Dyphylline-Probenecid Interaction (Severity Level: Minor)
Decreased renal excretion (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Dyphylline				Probenecid
Mechanism		Dyphylline				Inhibit the renal elimination of dyphylline
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the excretion of the drug, resulting in changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased renal excretion of Dyphylline caused by Probenecid

References
1	Acara M, Carr EA Jr, Terry EN "Probenecid inhibition of the renal excretion of dyphyllin in chicken, rat and man." J Pharm Pharmacol 39 (1987): 526-30. [PMID: 2886621]
2	May DC, Jarboe CH "Effect of probenecid on dyphylline elimination." Clin Pharmacol Ther 33 (1983): 822-5. [PMID: 6851414]
3	Nadai M, Apichartpichean R, Hasegawa T, Nabeshima T "Pharmacokinetics and the effect of probenecid on the renal excretion mechanism of diprophylline." J Pharm Sci 81 (1992): 1024-7. [PMID: 1432614]