Details of Drug

Drug General Information (ID: D0544)
Drug Name	Dyphylline
Drug Type	Small molecule
Drug Synonymous	Aristophyllin; Asthmolysin; Astmamasit; Astrophyllin; Circain; Circair; Coronal; Coronarin; Corphyllin; Dihydroxypropyltheophylline; Diprofilina; Diprofillin; Diprofillina; Diprofilline; Diprophyllin; Diprophylline; Diprophyllinum; Dipropylline; Droxine; Dyflex; Glyfyllin; Glyphyllin; Glyphylline; Glyphyllinum; Hidroxiteofillina; Hiphyllin; Hyphylline; Iphyllin; Isophyllen; Liactemin; Lufyllin; Neophyl; Neophyllin; Neophylline; Neostenovasan; Neothylline; Neotilina; Neufil; Neutrafil; Neutrafillina; Neutraphyllin; Neutraphylline; Neutroxantina; Propyphyllin; Protheophylline; Purifilin; Silbephyllin; Silbephylline; Solufilin; Solufyllin; Soluphyllin; Synthophylline; Tefilan; Teofen; Tesfen; Theal; Thefylan; Dihydroxypropyl theophylline; Dihydroxypropyl theopylin; Dilor G; Diprofillina [DCIT]; Dyphylline [USAN]; Neophyllin M; Theal ampules; AFI-Phyllin; COR-theophylline; Dihydroxypropyl theopylin (german); Dilor-400; Diphyllin (VAN); Diprofilina [INN-Spanish]; Diprophyllinum [INN-Latin]; Dyphylline (USP); Lufyllin (TN); Neo-Vasophylline; Diprophylline (JAN/INN); Neothylline, Lufyllin, diprophylline,Dyphylline; (+-)-7-(2,3-Dihydroxypropyl)theophylline; (+-)-diprophylline; (+-)-dyphylline; (1,2-Dihydroxy-3-propyl)thiophyllin; 1,3-Dimethyl-7-(2,3-dihydroxypropyl)xanthine; 1H-Purine-2,6-dione, 7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl; 7-(2,3-Dihydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione; 7-(2,3-Dihydroxypropyl)-1,3-dimethylxanthine; 7-(2,3-Dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione; 7-(2,3-Dihydroxypropyl)theophylline; 7-(2,3-Dioxypropyl)theophylline; 7-(2,3-dihydroxypropyl)-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione; 7-(2,3-dihydroxypropyl)-1,3-dimethylpurine-2,6-dione; 7-(beta,gamma-Dihydroxypropyl)theophylline; 7-(beta.,.gamma.-Dihydroxypropyl)theophylline; 7-DIHYDROXYPROPYLTHEOPHYLLINE; 7-[2,3-Dihydroxypropyl]-theophylline Click to Show/Hide
Disease Class	CA23: Asthma
Therapeutic Class	Bronchodilators
Structure
Structure	3D Structure		2D Structure
Formula	C10H14N4O4
InChI	1S/C10H14N4O4/c1-12-8-7(9(17)13(2)10(12)18)14(5-11-8)3-6(16)4-15/h5-6,15-16H,3-4H2,1-2H3
InChIKey	KSCFJBIXMNOVSH-UHFFFAOYSA-N
Canonical SMILES	CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(CO)O
External Link
	Pubchem ID	3182
	CAS Number	479-18-5
	CHEBI ID	4728
	TTD ID	D02PWM

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM003 Complex formation BM004 Adsorption BM017 CYP450 enzyme inhibition BM018 Non-CYP450 enzyme inhibition BM028 Competitive inhibition of renal tubular secretion BM032 Decreased renal excretion (Unspecific) BM042 Additive hypotensive effects BM065 Increased risk of hypokalemia BM087 Antagonize the effect of antiepileptic agents BM090 Antagonize the effect of bronchodilators BM095 Antagonize the effect of neuromuscular blocking agents BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Dyphylline
Affected gastrointestinal absorption
	Complex formation					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0381		Colesevelam	C31H67Cl3N4O	160051	Moderate		Inter Info	[44], [45]
	Adsorption					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0021		Activated charcoal	C	5462310	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0191		Blinatumomab	NA	NA	Moderate		Inter Info	[43]
	Non-CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0637		Febuxostat	C16H16N2O3S	134018	Moderate		Inter Info	[46]
Affected excretion pathways
	Competitive inhibition of renal tubular secretion					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0576		Entecavir	C12H15N5O3	135398508	Moderate		Inter Info	[47]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[48]
	Decreased renal excretion (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1341		Probenecid	C13H19NO4S	4911	Minor		Inter Info	[52], [53], [54]
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1408		Riociguat	C20H19FN8O2	11304743	Major		Inter Info	[6], [7], [8]
	Increased risk of hypokalemia					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[40], [41], [42]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[40], [41], [42]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[40], [41], [42]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[40], [41], [42]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[40], [41], [42]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[40], [41], [42]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[40], [41], [42]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[40], [41], [42]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[40], [41], [42]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[40], [41], [42]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[40], [41], [42]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[40], [41], [42]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[40], [41], [42]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0751		Halothane	C2HBrClF3	3562	Major		Inter Info	[4], [5]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antiepileptic agents					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0045		Alprazolam	C17H13ClN4	2118	Minor		Inter Info	[49], [50], [51]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Minor		Inter Info	[49], [50], [51]
D0356		Clobazam	C16H13ClN2O2	2789	Minor		Inter Info	[49], [50], [51]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Minor		Inter Info	[49], [50], [51]
D0362		Clonazepam	C15H10ClN3O3	2802	Minor		Inter Info	[49], [50], [51]
D0473		Diazepam	C16H13ClN2O	3016	Minor		Inter Info	[49], [50], [51]
D0604		Estazolam	C16H11ClN4	3261	Minor		Inter Info	[49], [50], [51]
D0679		Flurazepam	C21H23ClFN3O	3393	Minor		Inter Info	[49], [50], [51]
D0748		Halazepam	C17H12ClF3N2O	31640	Minor		Inter Info	[49], [50], [51]
D1060		Midazolam	C18H13ClFN3	4192	Minor		Inter Info	[49], [50], [51]
D1197		Oxazepam	C15H11ClN2O2	4616	Minor		Inter Info	[49], [50], [51]
D1367		Quazepam	C17H11ClF4N2S	4999	Minor		Inter Info	[49], [50], [51]
D1391		Remimazolam	C21H19BrN4O2	9867812	Minor		Inter Info	[49], [50], [51]
D1632		Triazolam	C17H12Cl2N4	5556	Minor		Inter Info	[49], [50], [51]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Minor		Inter Info	[49], [50], [51]
D1547		Temazepam	C16H13ClN2O2	5391	Minor		Inter Info	[49], [50], [51]
	Antagonize the effect of bronchodilators					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0117		Atenolol	C14H22N2O3	2249	Major		Inter Info	[1], [2], [3]
D0173		Betaxolol	C18H29NO3	2369	Major		Inter Info	[1], [2], [3]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Major		Inter Info	[1], [2], [3]
D0188		Bisoprolol	C18H31NO4	2405	Major		Inter Info	[1], [2], [3]
D0265		Carteolol	C16H24N2O3	2583	Major		Inter Info	[1], [2], [3]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Major		Inter Info	[1], [2], [3]
D0010		Acebutolol	C18H28N2O4	1978	Major		Inter Info	[1], [2], [3]
D0267		Carvedilol	C24H26N2O4	2585	Major		Inter Info	[1], [2], [3]
D0914		Levobetaxolol (ophthalmic)	C18H29NO3	60657	Major		Inter Info	[1], [2], [3]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Major		Inter Info	[1], [2], [3]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Major		Inter Info	[1], [2], [3]
D1098		Nadolol	C17H27NO4	39147	Major		Inter Info	[1], [2], [3]
D1114		Nebivolol	C22H25F2NO4	71301	Major		Inter Info	[1], [2], [3]
D1244		Penbutolol	C18H29NO2	37464	Major		Inter Info	[1], [2], [3]
D1293		Pindolol	C14H20N2O2	4828	Major		Inter Info	[1], [2], [3]
D0602		Esmolol	C16H25NO4	59768	Major		Inter Info	[1], [2], [3]
D0884		Labetalol	C19H24N2O3	3869	Major		Inter Info	[1], [2], [3]
D1049		Metoprolol	C15H25NO3	4171	Major		Inter Info	[1], [2], [3]
D1357		Propranolol	C16H21NO2	4946	Major		Inter Info	[1], [2], [3]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[1], [2], [3]
D1585		Timolol	C13H24N4O3S	33624	Major		Inter Info	[1], [2], [3]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Major		Inter Info	[1], [2], [3]
	Antagonize the effect of neuromuscular blocking agents					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[12], [13], [14]
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[12], [13], [14]
D0522		Doxacurium	C56H78N2O16+2	60169	Moderate		Inter Info	[12], [13], [14]
D1047		Metocurine	C40H48N2O6+2	21233	Moderate		Inter Info	[12], [13], [14]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[12], [13], [14]
D1219		Pancuronium	C35H60N2O4+2	441289	Moderate		Inter Info	[12], [13], [14]
D1295		Pipecuronium	C35H62N4O4+2	50192	Moderate		Inter Info	[12], [13], [14]
D1384		Rapacuronium	C37H61N2O4+	5311399	Moderate		Inter Info	[12], [13], [14]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[12], [13], [14]
D1659		Tubocurarine	C37H41N2O6+	6000	Moderate		Inter Info	[12], [13], [14]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[12], [13], [14]
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[12], [13], [14]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0025		Adenosine	C10H13N5O4	60961	Moderate		Inter Info	[9], [10], [11]
D0506		Dipyridamole	C24H40N8O4	3108	Moderate		Inter Info	[9], [10], [11]
D1877		Regadenoson	C15H18N8O5	219024	Moderate		Inter Info	[9], [10], [11]
D1356		Propofol	C12H18O	4943	Minor		Inter Info	[55], [56], [57]

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