Drug General Information (ID: DDINXQHOG3)
Drug Name			Dyphylline		Drug Info		Propofol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Bronchodilators				Anxiolytics/Sedatives/Hypnotics
Structure

Mechanism of Dyphylline-Propofol Interaction (Severity Level: Minor)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Dyphylline				Propofol
Mechanism		Antagonize the sedative effects of propofol				Propofol
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Dyphylline when combined with Propofol

References
1	Jonkman JH, Sollie FA, Sauter R, Steinijans VW "The influence of caffeine on the steady-state pharmacokinetics of theophylline." Clin Pharmacol Ther 49 (1991): 248-55. [PMID: 2007319]
2	Sato J, Nakata H, Owada E, Kikuta T, Umetsu M, Ito K "Influence of usual intake of dietary caffeine on single-dose kinetics of theophylline in healthy human subjects." Eur J Clin Pharmacol 44 (1993): 295-8. [PMID: 8491248]
3	Taylor BL, Collins C "Aminophylline and propofol: apparent antagonism." Anaesthesia 43 (1988): 508