Drug General Information (ID: D1356)
  Drug Name
Propofol
  Drug Type Small molecule
  Drug Synonymous
Ampofol; Aquafol; Diisopropylphenol; Dipravan; Diprivan; Disoprivan; Disoprofol; Fresofol; Ivofol; PFL; Propofolum; Rapinovet; Recofol; Abbott Brand of Propofol; Alpha Brand of Propofol; Astra Brand of Propofol; AstraZeneca Brand of Propofol; Braun Brand of Propofol; Curamed Brand of Propofol; Diprivan Injectable emulsion; Fresenius Brand of Propofol; Fresenius Kabi Brand of Propofol; Juste Brand of Propofol; Parnell Brand of Propofol; Pisa Brand of Propofol; Propofol Abbott; Propofol Fresenius; Propofol MCT; Propofol Rovi; Propofolum [Latin]; Rovi Brand of Propofol; Schering Brand of Propofol; Zeneca Brand of Propofol; AM-149; DDS-04F; Diprivan (TN); Propofol IDD-D; Propofol-Lipuro; ZD-0859; Ghl.PD_Mitscher_leg0.558; Propofol [USAN:INN:BAN]; Propofol (JAN/USAN/INN); Propofol(2,6-Diisopropylphenol); 2, 6-Diisopropylphenol; 2,6 Diisopropylphenol; 2,6-Bis(1-methylethyl)phenol; 2,6-Bis(Isopropyl)-phenol; 2,6-DIISOPROPYLPHENOL; 2,6-Diisopropyl phenol; 2,6-Diisopropylphenol; 2,6-bis(1-methylethyl)-phenol; 2,6-di(propan-2-yl)phenol
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  Disease Class 9A76-9A78: Corneal disease
  Therapeutic Class Anxiolytics/Sedatives/Hypnotics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C12H18O
  InChI 1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3
  InChIKey OLBCVFGFOZPWHH-UHFFFAOYSA-N
  Canonical SMILES CC(C)C1=C(C(=CC=C1)C(C)C)O
  External Link
Pubchem ID 4943
CAS Number 2078-54-8
CHEBI ID 44915
TTD ID D0A3HB
INTEDE ID DR1365
VARIDT ID DR00424

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM017  CYP450 enzyme inhibition
BM022  CYP450 enzyme induction
BM036  Additive cardiorespiratory depression effects
BM038  Additive CNS depression effects
BM042  Additive hypotensive effects
BM051  Increased risk of bradycardia
BM069  Increased risk of lowers seizure threshold
BM076  Increased risk of prolong QT interval
BM081  Increased risk of ventricular arrhythmias
BM083  Potentiated the pharmacological effects (Unspecific)
BM107  Attenuated pharmacological effects (Unspecific)
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Propofol
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  4
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0002
 
Abametapir (topical)
 
C12H12N2
 
15664 
Moderate    Inter Info   
[87]
D0393
 
Crizotinib
 
C21H22Cl2FN5O
 
11626560 
Moderate    Inter Info   
[28], [29], [90]
D1063
 
Mifepristone
 
C29H35NO2
 
55245 
Moderate    Inter Info   
[103]
D1328
 
Prasugrel
 
C20H20FNO3S
 
6918456 
Minor    Inter Info   
[29], [118]
   CYP450 enzyme induction Drug Num:  7
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0044
 
Alpelisib
 
C19H22F3N5O2S
 
56649450 
Moderate    Inter Info   
[29], [88]
D0300
 
Cenobamate
 
C10H10ClN5O2
 
11962412 
Moderate    Inter Info   
[89]
D0406
 
Dabrafenib
 
C23H20F3N5O2S2
 
44462760 
Moderate    Inter Info   
[29], [91]
D0953
 
Lorlatinib
 
C21H19FN6O2
 
71731823 
Moderate    Inter Info   
[29]
D0958
 
Lumacaftor
 
C24H18F2N2O5
 
16678941 
Moderate    Inter Info   
[101], [29], [102]
D1167
 
Olaparib
 
C24H23FN4O3
 
23725625 
Moderate    Inter Info   
[28], [29], [104]
D1546
 
Telotristat ethyl
 
C27H26ClF3N6O3
 
25181577 
Moderate    Inter Info   
[29], [109]
      Pharmacodynamic additive effects
   Additive cardiorespiratory depression effects Drug Num:  74
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0035
 
Alfentanil
 
C21H32N6O3
 
51263 
Moderate    Inter Info   
[36], [37], [38], [39], [40], [41]
D0045
 
Alprazolam
 
C17H13ClN4
 
2118 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0222
 
Buspirone
 
C21H31N5O2
 
2477 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0224
 
Butabarbital
 
C10H16N2O3
 
2479 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0226
 
Butorphanol
 
C21H29NO2
 
5361092 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0317
 
Chlordiazepoxide
 
C16H14ClN3O
 
2712 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0356
 
Clobazam
 
C16H13ClN2O2
 
2789 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0365
 
Clorazepic acid
 
C16H11ClN2O3
 
2809 
Moderate    Inter Info   
[43], [38], [39]
D0379
 
Codeine
 
C18H21NO3
 
5284371 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0459
 
Dexmedetomidine
 
C13H16N2
 
5311068 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0467
 
Dextropropoxyphene
 
C22H29NO2
 
10100 
Moderate    Inter Info   
[43], [38], [39]
D0535
 
Droperidol
 
C22H22FN3O2
 
3168 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0570
 
Enflurane
 
C3H2ClF5O
 
3226 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0612
 
Eszopiclone
 
C17H17ClN6O3
 
969472 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0618
 
Ethchlorvynol
 
C7H9ClO
 
5281077 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0625
 
Etomidate
 
C14H16N2O2
 
667484 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0646
 
Fentanyl
 
C22H28N2O
 
3345 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0679
 
Flurazepam
 
C21H23ClFN3O
 
3393 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0748
 
Halazepam
 
C17H12ClF3N2O
 
31640 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0776
 
Hydromorphone
 
C17H19NO3
 
5284570 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0855
 
Isoflurane
 
C3H2ClF5O
 
3763 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0951
 
Lorazepam
 
C15H10Cl2N2O2
 
3958 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1001
 
Meperidine
 
C15H21NO2
 
4058 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1005
 
Meprobamate
 
C9H18N2O4
 
4064 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1017
 
Methadone
 
C21H27NO
 
4095 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1024
 
Methohexital
 
C14H18N2O3
 
9034 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1060
 
Midazolam
 
C18H13ClFN3
 
4192 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1089
 
Morphine
 
C17H19NO3
 
5288826 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1090
 
Morphine (liposomal)
 
C17H19NO3
 
5288826 
Moderate    Inter Info   
[43], [38], [39]
D1203
 
Oxycodone
 
C18H21NO4
 
5284603 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1247
 
Pentazocine
 
C19H27NO
 
441278 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1248
 
Pentobarbital
 
C11H18N2O3
 
4737 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1355
 
Propiomazine
 
C20H24N2OS
 
4940 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0071
 
Amobarbital
 
C11H18N2O3
 
2164 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0161
 
Benzhydrocodone
 
C25H25NO4
 
49836084 
Moderate    Inter Info   
[43], [38], [39]
D0219
 
Buprenorphine
 
C29H41NO4
 
644073 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0311
 
Chloral hydrate
 
C2H3Cl3O2
 
2707 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0318
 
Chlormezanone
 
C11H12ClNO3S
 
2717 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0362
 
Clonazepam
 
C15H10ClN3O3
 
2802 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0445
 
Desflurane
 
C3H2F6O
 
42113 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0470
 
Dezocine
 
C16H23NO
 
3033053 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0471
 
Diamorphine
 
C21H23NO5
 
5462328 
Moderate    Inter Info   
[43], [38], [39]
D0473
 
Diazepam
 
C16H13ClN2O
 
3016 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0475
 
Dichloralphenazone
 
C15H18Cl6N2O5
 
10188 
Moderate    Inter Info   
[43], [38], [39]
D0493
 
Dihydrocodeine
 
C18H23NO3
 
5284543 
Moderate    Inter Info   
[43], [38], [39]
D0604
 
Estazolam
 
C16H11ClN4
 
3261 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0665
 
Flibanserin
 
C20H21F3N4O
 
6918248 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0751
 
Halothane
 
C2HBrClF3
 
3562 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0772
 
Hydrocodone
 
C18H21NO3
 
5284569 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0879
 
Ketamine
 
C13H16ClNO
 
3821 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0901
 
Lemborexant
 
C22H20F2N4O2
 
56944144 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D0909
 
Levacetylmethadol
 
C23H31NO2
 
15130 
Moderate    Inter Info   
[43], [38], [39]
D1030
 
Methoxyflurane
 
C3H4Cl2F2O
 
4116 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1040
 
Methylphenobarbital
 
C13H14N2O3
 
8271 
Moderate    Inter Info   
[43], [38], [39]
D1100
 
Nalbuphine
 
C21H27NO4
 
5311304 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1183
 
Opium
 
NA
 
NA
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1197
 
Oxazepam
 
C15H11ClN2O2
 
4616 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1208
 
Oxymorphone
 
C17H19NO4
 
5284604 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1224
 
Paraldehyde
 
C6H12O3
 
31264 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1265
 
Phenobarbital
 
C12H12N2O3
 
4763 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1367
 
Quazepam
 
C17H11ClF4N2S
 
4999 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1378
 
Ramelteon
 
C16H21NO2
 
208902 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1390
 
Remifentanil
 
C20H28N2O5
 
60815 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1463
 
Sevoflurane
 
C4H3F7O
 
5206 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1524
 
Suvorexant
 
C23H23ClN6O2
 
24965990 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1536
 
Tasimelteon
 
C15H19NO2
 
10220503 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1632
 
Triazolam
 
C17H12Cl2N4
 
5556 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1716
 
Zaleplon
 
C17H15N5O
 
5719 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1453
 
Secobarbital
 
C12H18N2O3
 
5193 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1512
 
Sufentanil
 
C22H30N2O2S
 
41693 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1547
 
Temazepam
 
C16H13ClN2O2
 
5391 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1573
 
Thiopental
 
C11H18N2O2S
 
3000715 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1616
 
Tramadol
 
C16H25NO2
 
33741 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
D1729
 
Zolpidem
 
C19H21N3O
 
5732 
Moderate    Inter Info   
[36], [42], [43], [44], [38], [39]
   Additive CNS depression effects Drug Num:  12
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D1169
 
Oliceridine
 
C22H30N2O2S
 
66553195 
Major    Inter Info   
[4]
D1391
 
Remimazolam
 
C21H19BrN4O2
 
9867812 
Major    Inter Info   
[4]
D1485
 
Sodium oxybate
 
C4H7NaO3
 
23663870 
Major    Inter Info   
[14], [15]
D0097
 
Apomorphine
 
C17H17NO2
 
6005 
Moderate    Inter Info   
[45], [46]
D0206
 
Brimonidine (topical)
 
C11H10BrN5
 
2435 
Moderate    Inter Info   
[48], [29], [49]
D0305
 
Cetirizine
 
C21H25ClN2O3
 
2678 
Moderate    Inter Info   
[50], [51]
D1172
 
Olopatadine (nasal)
 
C21H23NO3
 
5281071 
Moderate    Inter Info   
[85], [86], [47]
D0098
 
Apraclonidine
 
C9H10Cl2N4
 
2216 
Moderate    Inter Info   
[48], [29], [49]
D0600
 
Esketamine
 
C13H16ClNO
 
182137 
Moderate    Inter Info   
[28], [95]
D0617
 
Ethanol
 
C2H6O
 
702 
Moderate    Inter Info   
[85], [96], [97], [29], [47]
D0917
 
Levocetirizine
 
C21H25ClN2O3
 
1549000 
Moderate    Inter Info   
[50], [51]
D1569
 
Thalidomide
 
C13H10N2O4
 
5426 
Moderate    Inter Info   
[110], [29], [28]
   Additive hypotensive effects Drug Num:  11
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0068
 
Amitriptyline
 
C20H23N
 
2160 
Moderate    Inter Info   
[29]
D0072
 
Amoxapine
 
C17H16ClN3O
 
2170 
Moderate    Inter Info   
[29]
D0795
 
Imipramine
 
C19H24N2
 
3696 
Moderate    Inter Info   
[29]
D1158
 
Nortriptyline
 
C19H21N
 
4543 
Moderate    Inter Info   
[29]
D0361
 
Clomipramine
 
C19H23ClN2
 
2801 
Moderate    Inter Info   
[29]
D0444
 
Deserpidine
 
C32H38N2O8
 
8550 
Moderate    Inter Info   
[92], [93]
D0446
 
Desipramine
 
C18H22N2
 
2995 
Moderate    Inter Info   
[29]
D0525
 
Doxepin
 
C19H21NO
 
667477 
Moderate    Inter Info   
[29]
D1361
 
Protriptyline
 
C19H21N
 
4976 
Moderate    Inter Info   
[29]
D1393
 
Reserpine
 
C33H40N2O9
 
5770 
Moderate    Inter Info   
[92], [93]
D1647
 
Trimipramine
 
C20H26N2
 
5584 
Moderate    Inter Info   
[29]
   Increased risk of bradycardia Drug Num:  1
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D1510
 
Succinylcholine
 
C14H30N2O4+2
 
5314 
Moderate    Inter Info   
[111], [28], [29]
   Increased risk of lowers seizure threshold Drug Num:  1
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0678
 
Fluphenazine
 
C22H26F3N3OS
 
3372 
Moderate    Inter Info   
[28], [29]
   Increased risk of prolong QT interval Drug Num:  163
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D1223
 
Papaverine
 
C20H21NO4
 
4680 
Major    Inter Info   
[6], [7], [8], [9], [10], [11], [12], [13]
D0003
 
Abarelix
 
C72H95ClN14O14
 
16131215 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0036
 
Alfuzosin
 
C19H27N5O4
 
2092 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0084
 
Anagrelide
 
C10H7Cl2N3O
 
135409400 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0115
 
Astemizole
 
C28H31FN4O
 
2247 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0119
 
Atomoxetine
 
C17H21NO
 
54841 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0139
 
Azithromycin
 
C38H72N2O12
 
447043 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0320
 
Chloroquine
 
C18H26ClN3
 
2719 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0324
 
Chlorpromazine
 
C17H19ClN2S
 
2726 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0341
 
Ciprofloxacin
 
C17H18FN3O3
 
2764 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0342
 
Cisapride
 
C23H29ClFN3O4
 
6917698 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0370
 
Clozapine
 
C18H19ClN4
 
135398737 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0429
 
Daunorubicin
 
C27H29NO10
 
30323 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0430
 
Daunorubicin (liposomal)
 
C27H29NO10
 
30323 
Moderate    Inter Info   
[21], [24], [25]
D0508
 
Disopyramide
 
C21H29N3O
 
3114 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0513
 
Dofetilide
 
C19H27N3O5S2
 
71329 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0514
 
Dolasetron
 
C19H20N2O3
 
3033818 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0554
 
Efavirenz
 
C14H9ClF3NO2
 
64139 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0584
 
Epirubicin
 
C27H29NO11
 
41867 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0597
 
Erythromycin
 
C37H67NO13
 
12560 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0667
 
Fluconazole
 
C13H12F2N6O
 
3365 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0676
 
Fluoxetine
 
C17H18F3NO
 
3386 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0682
 
Flutamide
 
C11H11F3N2O3
 
3397 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0707
 
Galantamine
 
C17H21NO3
 
9651 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0737
 
Goserelin
 
C59H84N18O14
 
5311128 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0740
 
Grepafloxacin
 
C19H22FN3O3
 
72474 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0750
 
Haloperidol
 
C21H23ClFNO2
 
3559 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0781
 
Hydroxyzine
 
C21H27ClN2O2
 
3658 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0787
 
Ibutilide
 
C20H36N2O3S
 
60753 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0908
 
Leuprolide
 
C59H84N16O12
 
657181 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0992
 
Mefloquine
 
C17H16F6N2O
 
4046 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1075
 
Mirtazapine
 
C17H19N3
 
4205 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1092
 
Moxifloxacin
 
C21H24FN3O4
 
152946 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1137
 
Nilutamide
 
C12H10F3N3O4
 
4493 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1166
 
Olanzapine
 
C17H20N4S
 
135398745 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1193
 
Oxaliplatin
 
C8H14N2O4Pt
 
9887053 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1210
 
Oxytocin
 
C43H66N12O12S2
 
439302 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1216
 
Palonosetron
 
C19H24N2O
 
6337614 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1246
 
Pentamidine
 
C19H24N4O2
 
4735 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1254
 
Perflutren
 
C3F8
 
6432 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1346
 
Prochlorperazine
 
C20H24ClN3S
 
4917 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1351
 
Promazine
 
C17H20N2S
 
4926 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0007
 
Abiraterone
 
C24H31NO
 
132971 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0037
 
Alimemazine
 
C18H22N2S
 
5574 
Moderate    Inter Info   
[21], [24], [25]
D0067
 
Amisulpride
 
C17H27N3O4S
 
2159 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0095
 
Apalutamide
 
C21H15F4N5O2S
 
24872560 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0105
 
Aripiprazole
 
C23H27Cl2N3O2
 
60795 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0107
 
Arsenic trioxide
 
As2O3
 
14888 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0112
 
Asenapine
 
C17H16ClNO
 
3036780 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0149
 
Bedaquiline
 
C32H31BrN2O2
 
5388906 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0170
 
Bepridil
 
C24H34N2O
 
2351 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0180
 
Bicalutamide
 
C18H14F4N2O4S
 
2375 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0195
 
Bosutinib
 
C26H29Cl2N5O3
 
5328940 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0230
 
Cabozantinib
 
C28H24FN3O5
 
25102847 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0302
 
Ceritinib
 
C28H36ClN5O3S
 
57379345 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0336
 
Cilostazol
 
C20H27N5O2
 
2754 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0349
 
Clarithromycin
 
C38H69NO13
 
84029 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0358
 
Clofazimine
 
C27H22Cl2N4
 
2794 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0428
 
Dasatinib
 
C22H26ClN7O2S
 
3062316 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0437
 
Degarelix
 
C82H103ClN18O16
 
16136245 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0452
 
Deutetrabenazine
 
C19H27NO3
 
73437646 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0516
 
Donepezil
 
C24H29NO3
 
3152 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0526
 
Doxepin (topical)
 
C19H21NO
 
667477 
Moderate    Inter Info   
[21], [24], [25]
D0528
 
Doxorubicin
 
C27H29NO11
 
31703 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0529
 
Doxorubicin (liposomal)
 
C27H29NO11
 
31703 
Moderate    Inter Info   
[21], [24], [25]
D0534
 
Dronedarone
 
C31H44N2O5S
 
208898 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0569
 
Encorafenib
 
C22H27ClFN7O4S
 
50922675 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0577
 
Entrectinib
 
C31H34F2N6O2
 
25141092 
Moderate    Inter Info   
[28], [29], [94]
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0594
 
Eribulin
 
C40H59NO11
 
11354606 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0599
 
Escitalopram
 
C20H21FN2O
 
146570 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0636
 
Famotidine
 
C8H15N7O2S3
 
5702160 
Moderate    Inter Info   
[28], [29], [98]
D0661
 
Fingolimod
 
C19H33NO2
 
107970 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0664
 
Flecainide
 
C17H20F6N2O3
 
3356 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0712
 
Gatifloxacin
 
C19H22FN3O4
 
5379 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0716
 
Gemifloxacin
 
C18H20FN5O4
 
9571107 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0720
 
Gilteritinib
 
C29H44N8O3
 
49803313 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0725
 
Glasdegib
 
C21H22N6O
 
25166913 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0738
 
Granisetron
 
C18H24N4O
 
5284566 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0749
 
Halofantrine
 
C26H30Cl2F3NO
 
37393 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0758
 
Histrelin
 
C66H86N18O12
 
25077993 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0779
 
Hydroxychloroquine
 
C18H26ClN3O
 
3652 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0788
 
Idarubicin
 
C26H27NO9
 
42890 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0791
 
Iloperidone
 
C24H27FN2O4
 
71360 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0806
 
Inotuzumab ozogamicin
 
NA
 
NA
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0872
 
Ivosidenib
 
C28H22ClF3N6O3
 
71657455 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0880
 
Ketoconazole
 
C26H28Cl2N4O4
 
456201 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0894
 
Lapatinib
 
C29H26ClFN4O4S
 
208908 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0899
 
Lefamulin
 
C28H45NO5S
 
25185057 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0903
 
Lenvatinib
 
C21H19ClN4O4
 
9823820 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0919
 
Levofloxacin
 
C18H20FN3O4
 
149096 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0937
 
Lisdexamfetamine
 
C15H25N3O
 
11597698 
Moderate    Inter Info   
[29]
D0940
 
Lithium carbonate
 
CLi2O3
 
11125 
Moderate    Inter Info   
[21], [24], [25]
D0942
 
Lofexidine
 
C11H12Cl2N2O
 
30668 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0943
 
Lomefloxacin
 
C17H19F2N3O3
 
3948 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0947
 
Loperamide
 
C29H33ClN2O2
 
3955 
Moderate    Inter Info   
[99], [100]
D0948
 
Lopinavir
 
C37H48N4O5
 
92727 
Moderate    Inter Info   
[21], [24], [25]
D0960
 
Lumefantrine
 
C30H32Cl3NO
 
6437380 
Moderate    Inter Info   
[21], [24], [25]
D0965
 
Macimorelin
 
C26H30N6O3
 
9804938 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1010
 
Mesoridazine
 
C21H26N2OS2
 
4078 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1026
 
Methotrimeprazine
 
C19H24N2OS
 
72287 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1062
 
Midostaurin
 
C35H30N4O4
 
9829523 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1136
 
Nilotinib
 
C28H22F3N7O
 
644241 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1155
 
Norfloxacin
 
C16H18FN3O3
 
4539 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1165
 
Ofloxacin
 
C18H20FN3O4
 
4583 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1181
 
Ondansetron
 
C18H19N3O
 
4595 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1189
 
Osilodrostat
 
C13H10FN3
 
44139752 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1190
 
Osimertinib
 
C28H33N7O2
 
71496458 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1215
 
Paliperidone
 
C23H27FN4O3
 
115237 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1221
 
Panobinostat
 
C21H23N3O2
 
6918837 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1230
 
Pasireotide
 
C58H66N10O9
 
9941444 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1232
 
Pazopanib
 
C21H23N7O2S
 
10113978 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1290
 
Pimavanserin
 
C25H34FN3O2
 
10071196 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1292
 
Pimozide
 
C28H29F2N3O
 
16362 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1302
 
Pitolisant
 
C17H26ClNO
 
9948102 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1315
 
Posaconazole
 
C37H42F2N8O4
 
468595 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1339
 
Primaquine
 
C15H21N3O
 
4908 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1342
 
Probucol
 
C31H48O2S2
 
4912 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1343
 
Procainamide
 
C13H21N3O
 
4913 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1352
 
Promethazine
 
C17H20N2S
 
4927 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1353
 
Propafenone
 
C21H27NO3
 
4932 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1368
 
Quetiapine
 
C21H25N3O2S
 
5002 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1371
 
Quinidine
 
C20H24N2O2
 
441074 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1398
 
Ribociclib
 
C23H30N8O
 
44631912 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1404
 
Rilpivirine
 
C22H18N6
 
6451164 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1418
 
Rivastigmine
 
C14H22N2O2
 
77991 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1424
 
Romidepsin
 
C24H36N4O6S2
 
5352062 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1432
 
Rucaparib
 
C19H18FN3O
 
9931954 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1444
 
Saquinavir
 
C38H50N6O5
 
441243 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1461
 
Sertraline
 
C17H17Cl2N
 
68617 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1474
 
Siponimod
 
C29H35F3N2O3
 
44599207 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1491
 
Solifenacin
 
C23H26N2O2
 
154059 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1499
 
Sparfloxacin
 
C19H22F2N4O3
 
60464 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1522
 
Sunitinib
 
C22H27FN4O2
 
5329102 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1526
 
Tacrolimus
 
C44H69NO12
 
445643 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1542
 
Telavancin
 
C80H106Cl2N11O27P
 
3081362 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1544
 
Telithromycin
 
C43H65N5O10
 
3002190 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1560
 
Tetrabenazine
 
C19H27NO3
 
6018 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1634
 
Triclabendazole
 
C14H9Cl3N2OS
 
50248 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1637
 
Trifluoperazine
 
C21H24F3N3S
 
5566 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1651
 
Triptorelin
 
C64H82N18O13
 
25074470 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1673
 
Valbenazine
 
C24H38N2O4
 
24795069 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1681
 
Vandetanib
 
C22H24BrFN4O2
 
3081361 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1682
 
Vardenafil
 
C23H32N6O4S
 
135400189 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1687
 
Vemurafenib
 
C23H18ClF2N3O3S
 
42611257 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1372
 
Quinine
 
C20H24N2O2
 
3034034 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1383
 
Ranolazine
 
C24H33N3O4
 
56959 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1413
 
Risperidone
 
C23H27FN4O2
 
5073 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1497
 
Sorafenib
 
C21H16ClF3N4O3
 
216239 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1498
 
Sotalol
 
C12H20N2O3S
 
5253 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1525
 
Tacrine
 
C13H14N2
 
1935 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1533
 
Tamoxifen
 
C26H29NO
 
2733526 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1555
 
Terfenadine
 
C32H41NO2
 
5405 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1574
 
Thioridazine
 
C21H26N2S2
 
5452 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1596
 
Tizanidine
 
C9H8ClN5S
 
5487 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1612
 
Toremifene
 
C26H28ClNO
 
3005573 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1624
 
Trazodone
 
C19H22ClN5O
 
5533 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1638
 
Triflupromazine
 
C18H19F3N2S
 
5568 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1683
 
Vasopressin
 
C46H65N15O12S2
 
644077 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1689
 
Venlafaxine
 
C17H27NO2
 
5656 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1726
 
Ziprasidone
 
C21H21ClN4OS
 
60854 
Moderate    Inter Info   
[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1051
 
Metronidazole
 
C6H9N3O3
 
4173 
Minor    Inter Info   
[28], [115], [116], [117]
D1516
 
Sulfamethoxazole
 
C10H11N3O3S
 
5329 
Minor    Inter Info   
[26], [28], [29], [119], [120], [121], [122]
   Increased risk of ventricular arrhythmias Drug Num:  30
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Major    Inter Info   
[5]
D0025
 
Adenosine
 
C10H13N5O4
 
60961 
Moderate    Inter Info   
[26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D0854
 
Isoetharine
 
C13H21NO3
 
3762 
Moderate    Inter Info   
[52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81]
D0888
 
Lactulose
 
C12H22O11
 
11333 
Moderate    Inter Info   
[26], [28], [29], [82], [83], [84]
D1185
 
Orciprenaline
 
C11H17NO3
 
4086 
Moderate    Inter Info   
[65], [75], [78]
D0103
 
Arformoterol
 
C19H24N2O4
 
3083544 
Moderate    Inter Info   
[52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81]
D0184
 
Bisacodyl
 
C22H19NO4
 
2391 
Moderate    Inter Info   
[26], [28], [29], [82], [83], [84]
D0269
 
Castor oil
 
C57H104O9
 
14030006 
Moderate    Inter Info   
[26], [28], [29], [82], [83], [84]
D0691
 
Formoterol
 
C19H24N2O4
 
3410 
Moderate    Inter Info   
[52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81]
D0701
 
Frangula purshiana bark
 
NA
 
NA
Moderate    Inter Info   
[28], [29], [84]
D0731
 
Glycerin
 
C3H8O3
 
753 
Moderate    Inter Info   
[26], [28], [29], [82], [83], [84]
D0797
 
Indacaterol
 
C24H28N2O3
 
6918554 
Moderate    Inter Info   
[52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81]
D0859
 
Isoprenaline
 
C11H17NO3
 
3779 
Moderate    Inter Info   
[65], [75], [78]
D0887
 
Lactitol
 
C12H24O11
 
157355 
Moderate    Inter Info   
[26], [28], [29], [82], [83], [84]
D0924
 
Levosalbutamol
 
C13H21NO3
 
123600 
Moderate    Inter Info   
[65], [75], [78]
D0970
 
Magnesium citrate
 
C12H10Mg3O14
 
6099959 
Moderate    Inter Info   
[26], [28], [29], [82], [83], [84]
D0973
 
Magnesium hydroxide
 
H2MgO2
 
14791 
Moderate    Inter Info   
[26], [28], [29], [82], [83], [84]
D1069
 
Mineral oil
 
NA
 
NA
Moderate    Inter Info   
[26], [28], [29], [82], [83], [84]
D1171
 
Olodaterol
 
C21H26N2O5
 
11504295 
Moderate    Inter Info   
[52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81]
D1266
 
Phenolphthalein
 
C20H14O4
 
4764 
Moderate    Inter Info   
[26], [28], [29], [82], [83], [84]
D1287
 
Picosulfuric acid
 
C18H15NO8S2
 
5243 
Moderate    Inter Info   
[29], [105], [106]
D1298
 
Pirbuterol
 
C12H20N2O3
 
4845 
Moderate    Inter Info   
[52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81]
D1308
 
Polyethylene glycol (3350 with electrolytes)
 
C2H6O2
 
174 
Moderate    Inter Info   
[29], [105], [106]
D1309
 
Polyethylene glycol (3350)
 
C2H6O2
 
174 
Moderate    Inter Info   
[28], [29], [84]
D1414
 
Ritodrine
 
C17H21NO3
 
33572 
Moderate    Inter Info   
[52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81]
D1438
 
Salbutamol
 
C13H21NO3
 
2083 
Moderate    Inter Info   
[65], [75], [78]
D1440
 
Salmeterol
 
C25H37NO4
 
5152 
Moderate    Inter Info   
[52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81]
D1488
 
Sodium sulfate
 
Na2O4S
 
24436 
Moderate    Inter Info   
[29], [105], [106]
D1554
 
Terbutaline
 
C12H19NO3
 
5403 
Moderate    Inter Info   
[52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81]
D1695
 
Vilanterol
 
C24H33Cl2NO5
 
10184665 
Moderate    Inter Info   
[65], [75], [78]
   Potentiated the pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D1502
 
St. John's Wort
 
NA
 
NA
Moderate    Inter Info   
[107], [108]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  5
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D1263
 
Phenelzine
 
C8H12N2
 
3675 
Major    Inter Info   
[1], [2], [3]
D0853
 
Isocarboxazid
 
C12H13N3O2
 
3759 
Major    Inter Info   
[1], [2], [3]
D1455
 
Selegiline
 
C13H17N
 
26757 
Major    Inter Info   
[1], [2], [3]
D1620
 
Tranylcypromine
 
C9H11N
 
19493 
Major    Inter Info   
[1], [2], [3]
D0143
 
Baclofen
 
C10H12ClNO2
 
2284 
Moderate    Inter Info   
[28], [29], [47]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  4
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0544
 
Dyphylline
 
C10H14N4O4
 
3182 
Minor    Inter Info   
[112], [113], [114]
D0064
 
Aminophylline
 
C16H24N10O4
 
9433 
Minor    Inter Info   
[112], [113], [114]
D1201
 
Oxtriphylline
 
C12H21N5O3
 
656652 
Minor    Inter Info   
[112], [113], [114]
D1570
 
Theophylline
 
C7H8N4O2
 
2153 
Minor    Inter Info   
[112], [113], [114]
References
1 Product Information. Azilect (rasagiline). Teva Pharmaceuticals USA, North Wales, PA.
2 Product Information. Marplan (isocarboxazid) Roche Laboratories, Nutley, NJ.
3 Product Information. Nardil (phenelzine). Parke-Dvis, Morris Plains, NJ.
4 US Food and Drug Administration "FDA warns about serious risks and death when combining opioid pain or cough medicines with benzodiazepines requires its strongest warning.".
5 Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
6 Goto M, Sato M, Kitzazawa H, et.al "Papaverine-induced QT interval prolongation and ventricular fibrillation in a patient with a history of drug-induced QT prolongation." Intern Med 53 (2014): 1629-31. [PMID: 25088875]
7 Inoue T, Asahi S, Takayanagi K, Morooka S, Takabatake Y "QT prolongation and possibility of ventricular arrhythmias after intracoronary papaverine." Cardiology 84 (1994): 9-13. [PMID: 7511988]
8 Jain A, Jenkins MG "Intracoronary electrocardiogram during torsade des pointes secondary to intracoronary papaverine." Cathet Cardiovasc Diagn 18 (1989): 255-7. [PMID: 2605630]
9 Kern MJ, Deligonul U, Serota H, Gudipati C, Buckingham T "Ventricular arrhythmia due to intracoronary papaverine: analysis of QT intervals and coronary vasodilatory reserve." Cathet Cardiovasc Diagn 19 (1990): 229-36. [PMID: 2334953]
10 Nakayama M, Saito A, Kitazawa H, et.al "Papaverine-induced polymorphic ventricular tachycardia in relation to QTU and giant T-U waves in four cases." Intern Med 51 (2012): 351-6. [PMID: 22333368]
11 Nakayama M, Tanaka N, Sakoda K, et.al "Papaverine-induced polymorphic ventricular tachycardia during coronary flow reserve study of patients with moderate coronary artery disease." Circ J 79 (2015): 530-6. [PMID: 25746536]
12 Talman CL, Winniford MD, Rossen JD, Simonetti I, Kienzle MG, Marcus ML "Polymorphous ventricular tachycardia: a side effect of intracoronary papaverine." J Am Coll Cardiol 15 (1990): 275-8. [PMID: 2299067]
13 Vrolix M, Piessens J, De Geest H "Torsades de pointes after intracoronary papaverine." Eur Heart J 12 (1991): 273-6. [PMID: 2044564]
14 Product Information. Xyrem (sodium oxybate). Orphan Medical, Minnetonka, MN.
15 Product Information. Xywav (calcium/magnesium/potass/sodium oxybates). Jazz Pharmaceuticals, Palo Alto, CA.
16 Hanci V, Aydin M, Yurtlu BS, et.al "Anesthesia induction with sevoflurane and propofol: evaluation of P-wave dispersion, QT and corrected QT intervals." Kaohsiung J Med Sci 26 (2010): 470-7. [PMID: 20837343]
17 Kim DH, Kweon TD, Nam SB, Han DW, Cho WY, Lee JS "Effects of target concentration infusion of propofol and tracheal intubation on QTc interval." Anaesthesia 63 (2008): 1061-4. [PMID: 18717665]
18 Kleinsasser A, Kuenszberg E, Loeckinger A, et.al "Sevoflurane, but not propofol, significantly prolongs the Q-T interval." Anesth Analg 90 (2000): 25-7. [PMID: 10624970]
19 Kleinsasser A, Loeckinger A, Lindner KH, Keller C, Boehler M, Puehringer F "Reversing sevoflurane-associated Q-Tc prolongation by changing to propofol." Anaesthesia 56 (2001): 248-50. [PMID: 11251432]
20 Paventi S, Santevecchi A, Ranieri R "Effects of sevoflurane versus propofol on QT interval." Minerva Anestesiol 67 (2001): 637-40. [PMID: 11731753]
21 Scalese MJ, Herring HR, Rathburn RC, Skrepnek GH, Ripley TL "Propofol-associated QTc prolongation." Ther Adv Drug Saf 7 (2016): 68-78. [PMID: 27298717]
22 Staikou C, Stamelos M, Stavroulakis E "Impact of anaesthetic drugs and adjuvants on ECG markers of torsadogenicity." Br J Anaesth 112 (2014): 217-30. [PMID: 24305646]
23 Toyoda T, Terao Y, Oji M, Okada M, Fukusaki M, Sumikawa K "The interaction of antiemetic dose of droperidol with propofol on QT interval during anesthetic induction." J Anesth 27 (2013): 885-9. [PMID: 23660990]
24 Whyte SD, Booker PD, Buckley DG "The Effects of Propofol and Sevoflurane on the QT Interval and Transmural Dispersion of Repolarization in Children." Anesth Analg 100 (2005): 71-77. [PMID: 15616054]
25 Wutzler A, De Asmundis C, Matsuda H, et.al "Effects of propofol on ventricular repolarization and incidence of malignant arrhythmias in adults." J Electrocardiol 51 (2018): 170-4. [PMID: 29174097]
26 Canadian Pharmacists Association.
27 Celiker A, Tokel K, Cil E, Ozkutlu S, Ozme S "Adenosine induced torsades de pointes in a child with congenital long QT syndrome." Pacing Clin Electrophysiol 17 (1994): 1814-7. [PMID: 7838793]
28 Cerner Multum, Inc. "Australian Product Information.".
29 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
30 Teodorovich N, Margolin E, Kogan Y, Paz O, Swissa M. Torsades de pointes after adenosine administration. J Electrocardiol. 2016;49(2):171-173. [PMID: 26850499]
31 Harrington GR, Froelich EG "Adenosine-induced torsades de pointes." Chest 103 (1993): 1299-1301. [PMID: 8131497]
32 Mallet ML "Proarrhythmic effects of adenosine: a review of the literature." Emerg Med J 21 (2004): 408-10. [PMID: 15208219]
33 Michalets EL, Williams CR "Drug interactions with cisapride: clinical implications." Clin Pharmacokinet 39 (2000): 49-75. [PMID: 10926350]
34 Tachakra SS, Robinson S "Adenosine and cardiac arrhythmias." BMJ 305 (1992): 422. [PMID: 1392935]
35 Wesley RC Jr, Turnquest P "Torsades de pointe after intravenous adenosine in the presence of prolonged QT syndrome." Am Heart J 123 (1992): 794-6. [PMID: 1539535]
36 Gill SS, Wright EM, Reilly CS "Pharmacokinetic interaction of propofol and fentanyl: single bolus injection study." Br J Anaesth 65 (1990): 760-5. [PMID: 2265045]
37 IselinChaves IA, Flaishon R, Sebel PS, Howell S, Gan TJ, Sigl J, Ginsberg B, Glass PSA "The effect of the interaction of propofol and alfentanil on recall, loss of consciousness, and the bispectral index." Anesth Analg 87 (1998): 949-55. [PMID: 9768800]
38 Product Information. Diprivan (propofol). Zeneca Pharmaceuticals, Wilmington, DE.
39 Product Information. Lusedra (fospropofol). Eisai Inc, Teaneck, NJ.
40 Stanski DR, Shafer SL "Quantifying anesthetic drug interaction. Implications for drug dosing." Anesthesiology 83 (1995): 1-5. [PMID: 7604988]
41 Vuyk J, Lim T, Engbers FH, Burm AG, Vletter AA, Bovill JG "The pharmacodynamic interaction of propofol and alfentanil during lower abdominal surgery in women." Anesthesiology 83 (1995): 8-22. [PMID: 7605022]
42 Hamaoka N, Oda Y, Hase I, Mizutani K, Nakamoto T, Ishizaki T, Asada A "Propofol decreases the clearance of midazolam by inhibiting CYP3A4: An in vivo and in vitro study." Clin Pharmacol Ther 66 (1999): 110-7. [PMID: 10460064]
43 McClune S, McKay AC, Wright PM, et al "Synergistic interaction between midazolam and propofol." Br J Anaesth 69 (1992): 240-5. [PMID: 1389840]
44 Pavlin DJ, Coda B, Shen DD, et al "Effects of combining propofol and alfentanil on ventilation, analgesia, sedation, and emesis in human volunteers." Anesthesiology 84 (1996): 23-37. [PMID: 8572340]
45 Product Information. Apokyn (apomorphine). Mylan Pharmaceuticals Inc, Morgantown, WV.
46 Product Information. Zohydro ER (HYDROcodone). Zogenix, Inc, San Diego, CA.
47 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
48 Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
49 Product Information. Mirvaso (brimonidine topical). Galderma Laboratories Inc, Cranbury, NJ.
50 Product Information. Zyrtec (cetirizine). Pfizer US Pharmaceuticals, New York, NY.
51 Product Information. Xyzal (levocetirizine). UCB Pharma Inc, Smyrna, GA.
52 Bengtsson B, Fagerstrom PO "Extrapulmonary effects of terbutaline during prolonged administration." Clin Pharmacol Ther 31 (1982): 726-32. [PMID: 7042176]
53 Braden GL, vonOeyen PT, Germain MJ, Watson DJ, Haag BL "Ritodrine- and terbutaline-induced hypokalemia in preterm labor: Mechanisms and consequences." Kidney Int 51 (1997): 1867-75. [PMID: 9186877]
54 Clifton GD, Hunt BA, Patel RC, Burki NK "Effects of sequential doses of parenteral terbutaline on plasma levels of potassium and related cardiopulmonary responses." Am Rev Respir Dis 141 (1990): 575-9. [PMID: 2178522]
55 Dickens GR, Mccoy RA, West R, Stapczynski JS, Clifton GD "Effect of nebulized albuterol on serum potassium and cardiac rhythm in patients with asthma or chronic obstructive pulmonary disease." Pharmacotherapy 14 (1994): 729-33. [PMID: 7885977]
56 Ferguson GT, Funck-Brentano C, Fischer T, Darken P, Reisner C "Cardiovascular Safety of Salmeterol in COPD." Chest 123 (2003): 1817-24. [PMID: 12796155]
57 Gelmont DM, Balmes JR, Yee A "Hypokalemia induced by inhaled bronchodilators." Chest 94 (1988): 763-6. [PMID: 3168573]
58 Gross TL, Sokol RJ "Severe hypokalemia and acidosis: a potential complication of beta- adrenergic treatment." Am J Obstet Gynecol 138 (1980): 1225-6. [PMID: 7446635]
59 Hastwell G, Lambert BE "The effect of oral salbutamol on serum potassium and blood sugar." Br J Obstet Gynaecol 85 (1978): 767-9. [PMID: 708661]
60 Hurlbert BJ, Edelman JD, David K "Serum potassium levels during and after terbutaline." Anesth Analg 60 (1981): 723-5. [PMID: 7197475]
61 Hypokalaemia due to salbutamol overdosage. Br Med J (Clin Res Ed) 283 (1981): 500-1. [PMID: 6114774]
62 Kantola I, Tarssanen L "Hypokalemia from usual salbutamol dosage ." Chest 89 (1986): 619-20. [PMID: 3956296]
63 Lowe MD, Rowland E, Brown MJ, Grace AA "Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium." Heart 86 (2001): 45-51. [PMID: 11410561]
64 Milic M, Bao X, Rizos D, Liu F, Ziegler MG "Literature review and pilot studies of the effect of qt correction formulas on reported beta(2)-agonist-induced QTc prolongation." Clin Ther 28 (2006): 582-90. [PMID: 16750469]
65 Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
66 Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
67 Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
68 Product Information. Foradil (formoterol) Novartis Pharmaceuticals, East Hanover, NJ.
69 Product Information. Maxair (pirbuterol). 3M Pharmaceuticals, St. Paul, MN.
70 Product Information. Proventil (albuterol). Schering Laboratories, Kenilworth, NJ.
71 Product Information. Severent (salmeterol). Glaxo Wellcome, Research Triangle Park, NC.
72 Product Information. Striverdi Respimat (olodaterol). Boehringer Ingelheim, Ridgefield, CT.
73 Product Information. Xopenex (levalbuterol). Sepracor, Marlborough, MA.
74 Rakhmanina NY, Kearns GL, Farrar HC "Hypokalemia in an asthmatic child from abuse of albuterol metered dose inhaler." Pediatr Emerg Care 14 (1998): 145-7. [PMID: 9583400]
75 Sanders JP, Potter DE, Ellis S, Bee DE, Grant JA "Metabolic and cardiovascular effects of carbuterol and metaproterenol." J Allergy Clin Immunol 60 (1977): 174-9. [PMID: 19514]
76 Sun ZH, Swan H, Vitasalo M, Toivonen L "Effects of epinephrine and phenylephrine on QT interval dispersion in congenital long QT syndrome." J Am Coll Cardiol 31 (1998): 1400-5. [PMID: 9581741]
77 Tveskov C, Djurhuus MS, Klitgaard NAH, Egstrup K "Potassium and magnesium distribution, ECG changes, and ventricular ectopic beats during beta(2)-adrenergic stimulation with terbutaline in healthy subjects." Chest 106 (1994): 1654-9. [PMID: 7988180]
78 Whyte KF, Addis GJ, Whitesmith R, Reid JL "The mechanism of salbutamol-induced hypokalaemia." Br J Clin Pharmacol 23 (1987): 65-71. [PMID: 3545273]
79 Windom H, Grainger J, Burgess C, Crane J, Pearce N, Beasley R "A comparison of the haemodynamic and hypokalaemic effects of inhaled pirbuterol and salbutamol." N Z Med J 103 (1990): 259-61. [PMID: 1972557]
80 Wong CS, Pavord ID, Williams J, Britton JR, Tattersfield AE "Bronchodilator, cardiovascular, and hypokalaemic effects of fenoterol, salbutamol, and terbutaline in asthma." Lancet 336 (1990): 1396-9. [PMID: 1978872]
81 Larsson S, Svedmyr N "Bronchodilating effect and side effects of beta2- adrenoceptor stimulants by different modes of administration (tablets, metered aerosol, and combinations thereof). A study with salbutamol inasthmatics." Am Rev Respir Dis 116 (1977): 861-9. [PMID: 921062]
82 Chin RL "Laxative-induced hypokalemia." Ann Emerg Med 32 (1998): 517-8. [PMID: 9774942]
83 Muller-Lissner SA "Adverse effects of laxatives: fact and fiction." Pharmacology 47 (1993): 138-45. [PMID: 8234421]
84 Schaefer DC, Cheskin LJ "Constipation in the elderly." Am Fam Physician 58 (1998): 907-14. [PMID: 9767726]
85 Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
86 Product Information. Patanase (olopatadine nasal). Alcon Laboratories Inc, Fort Worth, TX.
87 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
88 Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
89 Product Information. Xcopri (cenobamate). SK Life Science, Inc., Paramus, NJ.
90 Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
91 Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
92 Ziegler CH, Lovette JB "Operative complications after therapy with reserpine and reserpine compounds." JAMA 176 (1961): 114-7
93 Jahr JS, Weber S "Ventricular dysrhythmias following an alfentanil anesthetic in a patient on reserpine for hypertension." Acta Anaesthesiol Scand 35 (1991): 788-9
94 Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
95 Product Information. Spravato (esketamine). Janssen Pharmaceuticals, Titusville, NJ.
96 Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
97 Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
98 Product Information. Pepcid (famotidine). Merck & Co, Inc, West Point, PA.
99 Eggleston W, Clark KH, Marraffa JM "Loperamide abuse associated with cardiac dysrhythmia and death." Ann Emerg Med 69 (2017): 83-6. [PMID: 27140747]
100 US Food and Drug Administration "FDA warns about serious heart problems with high doses of the antidiarrheal medicine loperamide (Imodium), including from abuse and misuse.".
101 Cerner Multum, Inc. "Canadian Product Information.".
102 Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
103 Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
104 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
105 Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
106 Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
107 Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
108 Crowe S, McKeating K "Delayed Emergence and St. John's Wort." Anesthesiology 96 (2002): 1025-7
109 Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
110 Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
111 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
112 Jonkman JH, Sollie FA, Sauter R, Steinijans VW "The influence of caffeine on the steady-state pharmacokinetics of theophylline." Clin Pharmacol Ther 49 (1991): 248-55. [PMID: 2007319]
113 Sato J, Nakata H, Owada E, Kikuta T, Umetsu M, Ito K "Influence of usual intake of dietary caffeine on single-dose kinetics of theophylline in healthy human subjects." Eur J Clin Pharmacol 44 (1993): 295-8. [PMID: 8491248]
114 Taylor BL, Collins C "Aminophylline and propofol: apparent antagonism." Anaesthesia 43 (1988): 508
115 Kounas SP, Letsas KP, Sideris A, Efraimidis M, Kardaras F "QT interval prolongation and torsades de pointes due to a coadministration of metronidazole and amiodarone." Pacing Clin Electrophysiol 28 (2005): 472-3. [PMID: 15869686]
116 Product Information. Flagyl (metronidazole). Searle, Skokie, IL.
117 Product Information. Pylera (bismuth subcitrate potassium/metronidazo/TCN). Aptalis Pharma, Birmingham, AL.
118 Product Information. Effient (prasugrel). Lilly, Eli and Company, Indianapolis, IN.
119 Crouch MA, Limon L, Cassano AT "Clinical relevance and management of drug-related QT interval prolongation." Pharmacotherapy 23 (2003): 881-908. [PMID: 12885102]
120 Darpo B "Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes." Eur Heart J Suppl 3(Suppl K) (2001): K70-80.
121 Lopez JA, Harold JG, Rosenthal MC, Oseran DS, Schapira JN, Peter T "QT prolongation and torsades de pointes after administration of trimethoprin-sulfamethoxazole." Am J Cardiol 59 (1987): 376-7. [PMID: 3492908]
122 Wiener I, Rubin D, Martinez E, et al "QT prolongation and paroxysmal ventricular tachycardia occurring during fever following trimethoprim-sulfamethoxazole administration." Mt Sinai J Med 48 (1981): 53-5. [PMID: 6970886]