Drug General Information (ID: DDIVPXM76E)
Drug Name			Propofol		Drug Info		St. John's Wort		Drug Info
Drug Type		Small molecule				Natural product
Therapeutic Class		Anxiolytics/Sedatives/Hypnotics				Herbal Products/Antidepressants

Mechanism of Propofol-St. John's Wort Interaction (Severity Level: Moderate)
Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Propofol				St. John's Wort
Mechanism		General anesthetic				Prolong the sedative effect of general anesthetic
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of Propofol and St. John's Wort

Recommended Action
Management		Based on the suspected interaction, it may be appropriate to advise patients to discontinue use of St. John's wort 5 days before surgery.

References
1	Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
2	Crowe S, McKeating K "Delayed Emergence and St. John's Wort." Anesthesiology 96 (2002): 1025-7