Drug General Information (ID: DDI9D8L6ME)
Drug Name			Succinylcholine		Drug Info		Propofol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Anxiolytics/Sedatives/Hypnotics
Structure

Mechanism of Succinylcholine-Propofol Interaction (Severity Level: Moderate)
Increased risk of bradycardia Click to Show/Hide Mechanism Graph
Drug Name		Succinylcholine				Propofol
Mechanism		Bradycardia				Bradycardia
Key Mechanism Factor 1
		Factor Name		Bradycardia
		Factor Description		Bradycardia is a slow heart rate in which the heart beats less than 60 times per minute. If the heart rate is very slow and the heart is not pumping enough oxygen-rich blood to the body, and you may feel dizzy, very tired or weak, and short of breath.
Mechanism Description		Increased risk of bradycardia by the combination of Succinylcholine and Propofol

Recommended Action
Management		In general, anesthetics should be administered only by health care providers specially trained in the use of these agents and in the care of anesthetized patients. Administration of an anticholinergic agents before induction and during anesthesia is recommended to avoid the the occurrence of bradycardia.

References
1	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
2	Cerner Multum, Inc. "Australian Product Information.".
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".