Drug General Information (ID: DDIJD7K6T0)
Drug Name			Probenecid		Drug Info		Glycerol phenylbutyrate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Uricosuric Agents				Urea Cycle Disorder Agents
Structure

Mechanism of Probenecid-Glycerol phenylbutyrate Interaction (Severity Level: Major)
Decreased renal excretion (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Probenecid				Glycerol phenylbutyrate
Mechanism		Inhibit the renal excretion of metabolites of phenylbutyrate				Phenylbutyrate
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the excretion of the drug, resulting in changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased renal excretion of Glycerol phenylbutyrate caused by Probenecid

Recommended Action
Management		Since plasma PAA and urinary PAGN levels may be used to help guide dosing of phenylbutyrate therapy, caution is advised if probenecid is coadministered. The potential for increased risk of PAA-induced neurotoxicity should also be considered.

References
1	Product Information. Buphenyl (sodium phenylbutyrate). Horizon Pharma USA Inc, Northbrook, IL.
2	Product Information. Ravicti (glycerol phenylbutyrate). Hyperion Therapeutics Inc, South San Francisco, CA.