Details of Drug

Drug General Information (ID: D0732)
Drug Name	Glycerol phenylbutyrate
Drug Type	Small molecule
Drug Synonymous	GT4P; HPN-100; Glyceryl tri-(4-phenylbutyrate) Click to Show/Hide
Disease Class	DB90-DB9Z: Liver disease
Therapeutic Class	Urea Cycle Disorder Agents
Structure
Structure	3D Structure		2D Structure
Formula	C33H38O6
InChI	1S/C33H38O6/c34-31(22-10-19-27-13-4-1-5-14-27)37-25-30(39-33(36)24-12-21-29-17-8-3-9-18-29)26-38-32(35)23-11-20-28-15-6-2-7-16-28/h1-9,13-18,30H,10-12,19-26H2
InChIKey	ZSDBFLMJVAGKOU-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C=C1)CCCC(=O)OCC(COC(=O)CCCC2=CC=CC=C2)OC(=O)CCCC3=CC=CC=C3
External Link
	Pubchem ID	10482134
	CAS Number	611168-24-2
	CHEBI ID	134745
	TTD ID	D0E0BD

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM009 Altered absorption (Unspecific) BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM032 Decreased renal excretion (Unspecific) BM056 Increased risk of hyperammonemia BM088 Antagonize the effect of anti-hyperammonemia agents
Relation Graph

Full list of drugs interacting with Glycerol phenylbutyrate
Affected gastrointestinal absorption
	Altered absorption (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1187		Orlistat	C29H53NO5	3034010	Moderate		Inter Info	[20], [4]
D1218		Pancrelipase	C8H8Na2O5	8519	Moderate		Inter Info	[20], [4]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 98
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[1]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[20], [4]
D0011		Acetaminophen	C8H9NO2	1983	Moderate		Inter Info	[20], [4]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[20], [4]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[20], [4]
D0074		Amphetamine	C9H13N	3007	Moderate		Inter Info	[20], [4]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[21]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[20], [4]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[22], [23], [24]
D0165		Benzphetamine	C17H21N	5311017	Moderate		Inter Info	[20], [4]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Moderate		Inter Info	[20], [4]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[20], [4]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[20], [4]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[20], [4]
D0338		Cinacalcet	C22H22F3N	156419	Moderate		Inter Info	[20], [4]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[20], [4]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[20], [4]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[20], [4]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[20], [4]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[31], [23]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[20], [4]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[20], [4]
D0465		Dextroamphetamine	C9H13N	5826	Moderate		Inter Info	[20], [4]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[25], [20], [33], [34], [23], [35]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[20], [4]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[20], [4]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[20], [4]
D0514		Dolasetron	C19H20N2O3	3033818	Moderate		Inter Info	[20], [4]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[20], [4]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[37], [38]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[20], [4]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[20], [4]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[20], [4]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[20], [4]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[20], [4]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[20], [4]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[20], [4]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[20], [4]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[20], [4]
D0778		Hydroxyamphetamine (ophthalmic)	C9H13NO	3651	Moderate		Inter Info	[20], [4]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[20], [4]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[20], [15], [60]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[20], [4]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[20], [4]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[20], [4]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[20], [4]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[20], [4]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[20], [4]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Moderate		Inter Info	[20], [4]
D0950		Loratadine	C22H23ClN2O2	3957	Moderate		Inter Info	[20], [4]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[20], [4]
D0987		Meclizine	C25H27ClN2	4034	Moderate		Inter Info	[20], [4]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[20], [4]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[20], [4]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[20], [4]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[20], [4]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[20], [4]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[20], [4]
D1074		Mirabegron	C21H24N4O2S	9865528	Moderate		Inter Info	[20], [4]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[20], [4]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[20], [4]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[20], [4]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[20], [4]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[20], [4]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[20], [4]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[20], [4]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[20], [4]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[20], [4]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[20], [4]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[20], [4]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[20], [4]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[20], [4]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[20], [4]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[20], [4]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[20], [4]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[20], [4]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[20], [4]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[20], [4]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[20], [4]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[20], [4]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[20], [4]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[20], [4]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[20], [4]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[20], [4]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[20], [4]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[20], [4]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[82], [83], [84]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[20], [4]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[20], [4]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[20], [4]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[20], [4]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[20], [4]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[20], [4]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[20], [4]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[85], [15], [86], [87]
D1383		Ranolazine	C24H33N3O4	56959	Minor		Inter Info	[89]
D1607		Tolterodine	C22H31NO	443879	Minor		Inter Info	[90], [91], [15]
	CYP450 enzyme induction					Drug Num: 66
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[2]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[20], [4]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[20], [4]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[26], [27], [28]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[29], [20], [30]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[20], [4]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[25], [20], [32]
D0450		Desogestrel	C22H30O	40973	Moderate		Inter Info	[20], [4]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[25], [20], [36]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[20], [4]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[20], [4]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[20], [4]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[20], [4]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[20], [4]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[20], [4]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[39]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[40]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[20], [41]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[20], [42], [43]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[44]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[45]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Moderate		Inter Info	[46], [47]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[48]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[49]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[50]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[51]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[52]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[25], [20], [53]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[54]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[25], [55]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[56]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[57]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[58]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[20], [59]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[25], [20], [61]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[25], [62]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[20], [63]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[64]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[20], [65], [66]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[67]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[68]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[69]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[70]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[71], [72], [25], [20], [65], [73]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[20], [4]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[74]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[20], [4]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[25], [20], [36]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[25], [20], [36]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[20], [4]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[20], [4]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[75]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[20], [4]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[76], [25], [77], [78]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[20], [4]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[25], [29], [20], [79]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[25], [20], [80]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[20], [4]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[20], [4]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[25], [20], [81]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[20], [4]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[20], [4]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[20], [4]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[20], [4]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[20], [4]
D0700		Fostemsavir	C25H26N7O8P	11319217	Minor		Inter Info	[88]
Affected excretion pathways
	Decreased renal excretion (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1341		Probenecid	C13H19NO4S	4911	Major		Inter Info	[3], [4]
Pharmacodynamic additive effects
	Increased risk of hyperammonemia					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[25], [3], [4]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[25], [3], [4]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[25], [3], [4]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[25], [3], [4]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[25], [3], [4]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[25], [3], [4]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[25], [3], [4]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[25], [3], [4]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[25], [3], [4]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[25], [3], [4]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[25], [3], [4]
D1609		Topiramate	C12H21NO8S	5284627	Moderate		Inter Info	[25], [3], [4]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[25], [3], [4]
Pharmacodynamic antagonistic effects
	Antagonize the effect of anti-hyperammonemia agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1677		Valproic acid	C8H16O2	3121	Major		Inter Info	[18], [4], [19]

References
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3	Product Information. Buphenyl (sodium phenylbutyrate). Horizon Pharma USA Inc, Northbrook, IL.
4	Product Information. Ravicti (glycerol phenylbutyrate). Hyperion Therapeutics Inc, South San Francisco, CA.
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