Details of Drug-Drug Interaction
| Drug General Information (ID: DDIJT730CN) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Pancrelipase | Drug Info | Glycerol phenylbutyrate | Drug Info | |||||
| Drug Type | Protein/peptide | Small molecule | |||||||
| Therapeutic Class | Digestive Enzymes | Urea Cycle Disorder Agents | |||||||
| Structure | |||||||||
| Mechanism of Pancrelipase-Glycerol phenylbutyrate Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph | |||||||||
| Drug Name | Pancrelipase | Glycerol phenylbutyrate | |||||||
| Mechanism | Pancreatic enzymes | Absorption increased by pancreatic enzymes | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Pharmacokinetic | ||||||||
| Factor Description | Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Management | Caution and close monitoring of ammonia levels is recommended if glycerol phenylbutyrate is to be administered with pancreatic enzyme replacement therapies containing lipase. The dose of glycerol phenylbutyrate should be adjusted as necessary per local guidelines. | ||||||||
| References | |||||||||||||||||||
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| 1 | Cerner Multum, Inc. "UK Summary of Product Characteristics.". | ||||||||||||||||||
| 2 | Product Information. Ravicti (glycerol phenylbutyrate). Hyperion Therapeutics Inc, South San Francisco, CA. | ||||||||||||||||||