Drug General Information (ID: DDIY2RZO84)
Drug Name			Probenecid		Drug Info		Pegloticase		Drug Info
Drug Type		Small molecule				Protein/peptide
Therapeutic Class		Uricosuric Agents				Antihyperuricemic Agents

Mechanism of Probenecid-Pegloticase Interaction (Severity Level: Major)
Antagonize the effect of uricosuric agents Click to Show/Hide Mechanism Graph
Drug Name		Probenecid				Pegloticase
Mechanism		Uricosuric effects				Potentially blunt the rise of serum uric acid levels
Key Mechanism Factor 1
		Factor Name		Uricosuric agents
		Factor Description		The beneficial effects of uricosuric agents may be reduced, leading to an increased risk of hyperuricemia and gout.
Mechanism Description		Antagonize the effect of Probenecid when combined with Pegloticase

Recommended Action
Management		Oral urate-lowering medications should be discontinued prior to initiation of pegloticase and not used during pegloticase treatment.

References
1	Product Information. Krystexxa (pegloticase). Savient Pharmaceuticals, East Brunswick, NJ.