Details of Drug

Drug General Information (ID: D1860)
Drug Name	Pegloticase
Drug Type	Protein/peptide
Drug Synonymous	Krystexxa (TN) Click to Show/Hide
Disease Class	FA25: Gout
Therapeutic Class	Antihyperuricemic Agents
External Link
External Link	TTD ID	D06ZIT

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM048 Increased risk of angioedema/anaphylactoid reactions BM099 Antagonize the effect of uricosuric agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Pegloticase
Pharmacodynamic additive effects
	Increased risk of angioedema/anaphylactoid reactions					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1861		Pegvaliase	C15H30N2O5	86278362	Moderate		Inter Info	[2]
Pharmacodynamic antagonistic effects
	Antagonize the effect of uricosuric agents					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0040		Allopurinol	C5H4N4O	135401907	Major		Inter Info	[1]
D1341		Probenecid	C13H19NO4S	4911	Major		Inter Info	[1]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Major		Inter Info	[1]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1858		Pegademase	NA	NA	Moderate		Inter Info	[1]
D1859		Pegaptanib (ophthalmic)	C22H44N3O10P	56603655	Moderate		Inter Info	[1]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[1]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[1]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[1]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[1]
D1862		Pegvisomant	NA	NA	Moderate		Inter Info	[1]

References
1	Product Information. Krystexxa (pegloticase). Savient Pharmaceuticals, East Brunswick, NJ.
2	Product Information. Palynziq (pegvaliase). BioMarin Pharmaceutical Inc, Novato, CA.