Drug General Information (ID: DDIDJYW143)
Drug Name			Pegaspargase		Drug Info		Pegloticase		Drug Info
Drug Type		Small molecule				Protein/peptide
Therapeutic Class		Antineoplastics				Antihyperuricemic Agents

Mechanism of Pegaspargase-Pegloticase Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Pegaspargase				Pegloticase
Mechanism		Reduces pharmacological effects of pegloticase				Pegloticase
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Pegloticase when combined with Pegaspargase

Recommended Action
Management		Clinicians should be aware of the potential for diminished effects of other pegylated agents following treatment with pegloticase.

References
1	Product Information. Krystexxa (pegloticase). Savient Pharmaceuticals, East Brunswick, NJ.