Drug General Information (ID: DDIVWE0L7Z)
Drug Name			Probenecid		Drug Info		Doripenem		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Uricosuric Agents				Carbapenems
Structure

Mechanism of Probenecid-Doripenem Interaction (Severity Level: Moderate)
Competitive inhibition of renal tubular secretion Click to Show/Hide Mechanism Graph
Drug Name		Probenecid				Doripenem
Mechanism		Competitive inhibition of renal tubular secretion of some cephalosporins				Cephalosporins
Key Mechanism Factor 1
		Factor Name		Renal tubular secretion
		Factor Description		Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion.
Mechanism Description		Decreased elimination of Doripenem caused by Probenecid mediated competitive inhibition of renal tubular secretion

Recommended Action
Management		The use of doripenem in combination with probenecid is not recommended by the manufacturer.

References
1	Product Information. Doribax (doripenem). Ortho McNeil Pharmaceutical, Raritan, NJ.