Drug General Information (ID: DDI7X6BL4O)
Drug Name			Mycophenolic acid		Drug Info		Probenecid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiviral Agents				Uricosuric Agents
Structure

Mechanism of Mycophenolic acid-Probenecid Interaction (Severity Level: Moderate)
Competitive inhibition of renal tubular secretion Click to Show/Hide Mechanism Graph
Drug Name		Mycophenolic acid				Probenecid
Mechanism		Mycophenolic acid				Competitive inhibition of renal tubular secretion of mycophenolic acid
Key Mechanism Factor 1
		Factor Name		Renal tubular secretion
		Factor Description		Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion.
Mechanism Description		Decreased elimination of Mycophenolic acid caused by Probenecid mediated competitive inhibition of renal tubular secretion

Recommended Action
Management		Caution is advised if mycophenolic acid products must be used concomitantly with probenecid. The dosage of one or both drugs may require adjustments.

References
1	Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.
2	Product Information. Myfortic (mycophenolic acid). Novartis Pharmaceuticals, East Hanover, NJ.