Details of Drug

Drug General Information (ID: D1095)
Drug Name	Mycophenolic acid
Drug Type	Small molecule
Drug Synonymous	Acide mycophenolique; Acide mycophenolique [INN-French]; Acido micofenolico; Acido micofenolico [INN-Spanish]; Acidum mycoph; Acidum mycophenolicum; CCRIS 5565; Lilly-68618; Ly 68618; Melbex; Micofenolico acido; Micofenolico acido [Spanish]; Mycophenolate; Mycophenolsaeure; Myfortic; NSC 129185; NSC-129185; UNII-HU9DX48N0T Click to Show/Hide
Disease Class	1D64: Middle East Respiratory Syndrome
Therapeutic Class	Antiviral Agents
Structure
Structure	3D Structure		2D Structure
Formula	C17H20O6
InChI	1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
InChIKey	HPNSFSBZBAHARI-RUDMXATFSA-N
Canonical SMILES	CC1=C2COC(=O)C2=C(C(=C1OC)CC=C(C)CCC(=O)O)O
External Link
	Pubchem ID	446541
	CAS Number	24280-93-1
	CHEBI ID	168396
	TTD ID	D0Z8EV
	INTEDE ID	DR1119
	VARIDT ID	DR01218

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM002 Altered intestinal flora BM003 Complex formation BM004 Adsorption BM005 Altered gastric pH BM010 Transporter inhibition BM011 Transporter induction BM012 Competitive inhibition of transporters BM013 Competitive binding of plasma proteins BM019 UGT inhibition BM022 CYP450 enzyme induction BM023 UGT induction BM028 Competitive inhibition of renal tubular secretion BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific) BM110 Antagonize the effects of immunosuppressants
Relation Graph

Full list of drugs interacting with Mycophenolic acid
Affected gastrointestinal absorption
	Altered intestinal flora					Drug Num: 107
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0056		Amikacin	C22H43N5O13	37768	Moderate		Inter Info	[9], [11]
D0079		Ampicillin	C16H19N3O4S	6249	Moderate		Inter Info	[9], [11]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[9], [11]
D0140		Aztreonam	C13H17N5O8S2	5742832	Moderate		Inter Info	[9], [11]
D0142		Bacitracin	C66H103N17O16S	10909430	Moderate		Inter Info	[9], [11]
D0257		Carbenicillin	C17H18N2O6S	20824	Moderate		Inter Info	[9], [11]
D0271		Cefaclor	C15H14ClN3O4S	51039	Moderate		Inter Info	[9], [11]
D0273		Cefalotin	C16H16N2O6S2	6024	Moderate		Inter Info	[9], [11]
D0277		Cefdinir	C14H13N5O5S2	6915944	Moderate		Inter Info	[9], [11]
D0281		Cefixime	C16H15N5O7S2	5362065	Moderate		Inter Info	[9], [11]
D0282		Cefmetazole	C15H17N7O5S3	42008	Moderate		Inter Info	[9], [11]
D0285		Cefotaxime	C16H17N5O7S2	5742673	Moderate		Inter Info	[9], [11]
D0292		Ceftazidime	C22H22N6O7S2	5481173	Moderate		Inter Info	[9], [11]
D0301		Cephalexin	C16H17N3O4S	27447	Moderate		Inter Info	[9], [11]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[9], [11]
D0340		Cinoxacin	C12H10N2O5	2762	Moderate		Inter Info	[9], [11]
D0421		Daptomycin	C72H101N17O26	16134395	Moderate		Inter Info	[9], [11]
D0441		Demeclocycline	C21H21ClN2O8	54680690	Moderate		Inter Info	[9], [11]
D0480		Dicloxacillin	C19H17Cl2N3O5S	18381	Moderate		Inter Info	[9], [11]
D0530		Doxycycline	C22H24N2O8	54671203	Moderate		Inter Info	[9], [11]
D0573		Enoxacin	C15H17FN4O3	3229	Moderate		Inter Info	[9], [11]
D0596		Ertapenem	C22H25N3O7S	150610	Moderate		Inter Info	[9], [11]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[9], [11]
D0718		Gentamicin	C21H43N5O7	3467	Moderate		Inter Info	[9], [11]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[9], [11]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[9], [11]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[9], [11]
D0949		Loracarbef	C16H16ClN3O4	5284585	Moderate		Inter Info	[9], [11]
D1008		Meropenem	C17H25N3O5S	441130	Moderate		Inter Info	[9], [11]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[9], [11]
D1055		Mezlocillin	C21H25N5O8S2	656511	Moderate		Inter Info	[9], [11]
D1070		Minocycline	C23H27N3O7	54675783	Moderate		Inter Info	[9], [11]
D1092		Moxifloxacin	C21H24FN3O4	152946	Moderate		Inter Info	[9], [11]
D0073		Amoxicillin	C16H19N3O5S	33613	Moderate		Inter Info	[9], [11]
D0141		Bacampicillin	C21H27N3O7S	441397	Moderate		Inter Info	[9], [11]
D0167		Benzylpenicillin	C16H18N2O4S	5904	Moderate		Inter Info	[9], [11]
D0168		Benzylpenicillin (potassium)	C16H18N2O4S	5904	Moderate		Inter Info	[9], [11]
D0169		Benzylpenicillin (sodium)	C16H18N2O4S	5904	Moderate		Inter Info	[9], [11]
D0272		Cefadroxil	C16H17N3O5S	47965	Moderate		Inter Info	[9], [11]
D0274		Cefamandole	C18H18N6O5S2	456255	Moderate		Inter Info	[9], [11]
D0275		Cefapirin	C17H17N3O6S2	30699	Moderate		Inter Info	[9], [11]
D0276		Cefazolin	C14H14N8O4S3	33255	Moderate		Inter Info	[9], [11]
D0278		Cefditoren	C19H18N6O5S3	9870843	Moderate		Inter Info	[9], [11]
D0279		Cefepime	C19H24N6O5S2	5479537	Moderate		Inter Info	[9], [11]
D0280		Cefiderocol	C30H34ClN7O10S2	77843966	Moderate		Inter Info	[9], [11]
D0283		Cefonicid	C18H18N6O8S3	43594	Moderate		Inter Info	[9], [11]
D0284		Cefoperazone	C25H27N9O8S2	44187	Moderate		Inter Info	[9], [11]
D0286		Cefotetan	C17H17N7O8S4	53025	Moderate		Inter Info	[9], [11]
D0287		Cefoxitin	C16H17N3O7S2	441199	Moderate		Inter Info	[9], [11]
D0288		Cefpodoxime	C15H17N5O6S2	6335986	Moderate		Inter Info	[9], [11]
D0289		Cefprozil	C18H19N3O5S	5281006	Moderate		Inter Info	[9], [11]
D0290		Cefradine	C16H19N3O4S	38103	Moderate		Inter Info	[9], [11]
D0291		Ceftaroline fosamil	C22H21N8O8PS4	9852981	Moderate		Inter Info	[9], [11]
D0293		Ceftibuten	C15H14N4O6S2	5282242	Moderate		Inter Info	[9], [11]
D0294		Ceftizoxime	C13H13N5O5S2	6533629	Moderate		Inter Info	[9], [11]
D0295		Ceftolozane	C23H30N12O8S2	53234134	Moderate		Inter Info	[9], [11]
D0296		Ceftriaxone	C18H18N8O7S3	5479530	Moderate		Inter Info	[9], [11]
D0297		Cefuroxime	C16H16N4O8S	5479529	Moderate		Inter Info	[9], [11]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[9], [11]
D0354		Clindamycin	C18H33ClN2O5S	446598	Moderate		Inter Info	[9], [11]
D0369		Cloxacillin	C19H18ClN3O5S	6098	Moderate		Inter Info	[9], [11]
D0383		Colistimethate	C58H105N16O28S5-5	70789202	Moderate		Inter Info	[9], [11]
D0411		Dalbavancin	C88H100Cl2N10O28	16134627	Moderate		Inter Info	[9], [11]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[9], [11]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Moderate		Inter Info	[9], [11]
D0519		Doripenem	C15H24N4O6S2	73303	Moderate		Inter Info	[9], [11]
D0589		Eravacycline	C27H31FN4O8	54726192	Moderate		Inter Info	[9], [11]
D0712		Gatifloxacin	C19H22FN3O4	5379	Moderate		Inter Info	[9], [11]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[9], [11]
D0794		Imipenem	C12H17N3O4S	104838	Moderate		Inter Info	[9], [11]
D0876		Kanamycin	C18H36N4O11	6032	Moderate		Inter Info	[9], [11]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[9], [11]
D0931		Lincomycin	C18H34N2O6S	3000540	Moderate		Inter Info	[9], [11]
D1044		Meticillin	C17H20N2O6S	6087	Moderate		Inter Info	[9], [11]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[9], [11]
D1159		Novobiocin	C31H36N2O11	54675769	Moderate		Inter Info	[9], [11]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[9], [11]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Moderate		Inter Info	[9], [11]
D1228		Paromomycin	C23H45N5O14	165580	Moderate		Inter Info	[9], [11]
D1304		Plazomicin	C25H48N6O10	42613186	Moderate		Inter Info	[9], [11]
D1452		Secnidazole	C7H11N3O3	71815	Moderate		Inter Info	[9], [11]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Moderate		Inter Info	[9], [11]
D1507		Streptomycin	C21H39N7O12	19649	Moderate		Inter Info	[9], [11]
D1514		Sulfadoxine	C12H14N4O4S	17134	Moderate		Inter Info	[9], [11]
D1539		Tedizolid	C17H15FN6O3	11234049	Moderate		Inter Info	[9], [11]
D1580		Ticarcillin	C15H16N2O6S2	36921	Moderate		Inter Info	[9], [11]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[9], [11]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[9], [11]
D1102		Nalidixic acid	C12H12N2O3	4421	Moderate		Inter Info	[9], [11]
D1120		Neomycin	C23H46N6O13	8378	Moderate		Inter Info	[9], [11]
D1126		Netilmicin	C21H41N5O7	441306	Moderate		Inter Info	[9], [11]
D1192		Oxacillin	C19H19N3O5S	6196	Moderate		Inter Info	[9], [11]
D1209		Oxytetracycline	C22H24N2O9	54675779	Moderate		Inter Info	[9], [11]
D1268		Phenoxymethylpenicillin	C16H18N2O5S	6869	Moderate		Inter Info	[9], [11]
D1296		Piperacillin	C23H27N5O7S	43672	Moderate		Inter Info	[9], [11]
D1310		Polymyxin B	C56H98N16O13	49800004	Moderate		Inter Info	[9], [11]
D1513		Sulfadiazine	C10H10N4O2S	5215	Moderate		Inter Info	[9], [11]
D1515		Sulfamethizole	C9H10N4O2S2	5328	Moderate		Inter Info	[9], [11]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Moderate		Inter Info	[9], [11]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[9], [11]
D1519		Sulfisoxazole	C11H13N3O3S	5344	Moderate		Inter Info	[9], [11]
D1564		Tetracycline	C22H24N2O8	54675776	Moderate		Inter Info	[9], [11]
D1582		Tigecycline	C29H39N5O8	54686904	Moderate		Inter Info	[9], [11]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[9], [11]
D1597		Tobramycin	C18H37N5O9	36294	Moderate		Inter Info	[9], [11]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Moderate		Inter Info	[9], [11]
D1680		Vancomycin	C66H75Cl2N9O24	14969	Moderate		Inter Info	[9], [11]
	Complex formation					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0381		Colesevelam	C31H67Cl3N4O	160051	Major		Inter Info	[9]
D0382		Colestipol	C11H28ClN5O	62816	Major		Inter Info	[9]
D0329		Cholestyramine	C27H47ClN2	137699107	Major		Inter Info	[9]
D0893		Lanthanum carbonate	C3La2O9	168924	Moderate		Inter Info	[57], [15], [7], [58], [59], [60]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[7], [74]
D1462		Sevelamer	C6H12ClNO	3085017	Moderate		Inter Info	[15], [7], [75], [9]
	Adsorption					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0021		Activated charcoal	C	5462310	Major		Inter Info	[9]
	Altered gastric pH					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[41], [42], [9], [11]
D0049		Aluminum hydroxide	AlH3O3	10176082	Moderate		Inter Info	[41], [42], [9], [11]
D0236		Calcium carbonate	CCaO3	10112	Moderate		Inter Info	[41], [42], [9], [11]
D0967		Magaldrate	AlHMgO5S+2	3086011	Moderate		Inter Info	[41], [42], [9], [11]
D0968		Magnesium carbonate	CMgO3	11029	Moderate		Inter Info	[41], [42], [9], [11]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[41], [42], [9], [11]
D0974		Magnesium oxide	MgO	14792	Moderate		Inter Info	[41], [42], [9], [11]
D1480		Sodium bicarbonate	CHNaO3	516892	Moderate		Inter Info	[41], [42], [9], [11]
D1483		Sodium citrate	C6H5Na3O7	6224	Moderate		Inter Info	[41], [42], [9], [11]
Affected cellular transport
	Transporter inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[37], [38], [39], [11], [40]
	Competitive inhibition of transporters					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[7], [23], [11]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0621		Ethotoin	C11H12N2O2	3292	Minor		Inter Info	[9]
D1003		Mephenytoin	C12H14N2O2	4060	Minor		Inter Info	[9]
D0064		Aminophylline	C16H24N10O4	9433	Minor		Inter Info	[9]
D0697		Fosphenytoin	C16H15N2O6P	56339	Minor		Inter Info	[9]
D1201		Oxtriphylline	C12H21N5O3	656652	Minor		Inter Info	[9]
D1283		Phenytoin	C15H12N2O2	1775	Minor		Inter Info	[9]
D1570		Theophylline	C7H8N4O2	2153	Minor		Inter Info	[9]
Affected intra/extra-hepatic metabolism
	UGT inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[56]
	CYP450 enzyme induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[7], [70]
	UGT induction					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[15], [7], [61]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[15], [7], [9]
Affected excretion pathways
	Competitive inhibition of renal tubular secretion					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0576		Entecavir	C12H15N5O3	135398508	Moderate		Inter Info	[44]
D1341		Probenecid	C13H19NO4S	4911	Moderate		Inter Info	[9], [11]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[73]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 29
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[7], [8]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[15], [7], [16]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[19]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[20], [21]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[7], [22]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[15], [24]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[20], [21]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[28]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[29]
D1111		Natalizumab	NA	NA	Major		Inter Info	[30]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[25], [31], [32]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[33]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[34], [35], [36]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[9]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[43]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[34], [35], [36]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[54]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[55]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[55]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[55]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[62]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[34], [35], [36]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[7], [71]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[72]
	Additive myelosuppressive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[15], [17], [18]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[12], [13], [14]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[12], [13], [14]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[12], [13], [14]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[12], [13], [14]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[12], [13], [14]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[25], [15], [26]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[27]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[12], [13], [14]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[12], [13], [14]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[12], [13], [14]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[45]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[25], [46], [47]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[25], [46], [47]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[25], [46], [47]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[25], [46], [47]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[25], [46], [47]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[25], [46], [47]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[25], [46], [47]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[25], [46], [47]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[63], [25], [15], [64], [65], [66], [46], [67], [68], [69], [47]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[25], [46], [47]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[25], [46], [47]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[25], [46], [47]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[48], [49], [50]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[48], [49], [50]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[51], [52], [53]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[51], [52], [53]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[51], [52], [53]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[51], [52], [53]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0619		Ethinylestradiol	C20H24O2	5991	Major		Inter Info	[10], [9], [11]
D0626		Etonogestrel	C22H28O2	6917715	Major		Inter Info	[10], [9], [11]
D0922		Levonorgestrel	C21H28O2	13109	Major		Inter Info	[10], [9], [11]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Major		Inter Info	[10], [9], [11]
D0485		Dienogest	C20H25NO2	68861	Major		Inter Info	[10], [9], [11]
D0536		Drospirenone	C24H30O3	68873	Major		Inter Info	[10], [9], [11]
D1011		Mestranol	C21H26O2	6291	Major		Inter Info	[10], [9], [11]
D1157		Norgestrel	C21H28O2	13109	Major		Inter Info	[10], [9], [11]
D1154		Norethisterone	C20H26O2	6230	Major		Inter Info	[10], [9], [11]
D1156		Norgestimate	C23H31NO3	6540478	Major		Inter Info	[10], [9], [11]
	Antagonize the effects of immunosuppressants					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0545		Echinacea	NA	NA	Minor		Inter Info	[76], [77], [78]
D1722		Zinc acetate	C4H6O4Zn	11192	Minor		Inter Info	[76], [77], [78]
D1723		Zinc chloride	Cl2Zn	5727	Minor		Inter Info	[76], [77], [78]
D1724		Zinc gluconate	C12H22O14Zn	443445	Minor		Inter Info	[76], [77], [78]
D1725		Zinc sulfate	O4SZn	24424	Minor		Inter Info	[76], [77], [78]
D1703		Vitamin E	C29H50O2	14985	Minor		Inter Info	[76], [77], [78]

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