Drug General Information (ID: DDI9DTMLQB)
Drug Name			Mycophenolic acid		Drug Info		Activated charcoal		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiviral Agents				Antidotes
Structure

Mechanism of Mycophenolic acid-Activated charcoal Interaction (Severity Level: Major)
Adsorption Click to Show/Hide Mechanism Graph
Drug Name		Mycophenolic acid				Activated charcoal
Mechanism		Adsorbed by activated charcoal				Activated charcoal
Key Mechanism Factor 1
		Factor Name		Adsorption
		Factor Description		Adsorption is a direct drug interaction, usually through adsorption on its surface, resulting in reduced absorption of concomitantly administered drugs in the gastrointestinal tract.
Mechanism Description		Decreased absorption of Mycophenolic acid due to adsorption of Activated charcoal

Recommended Action
Management		Given the risk of organ rejection associated with inadequate immunosuppressant blood levels, mycophenolic acid products should not be administered with cholestyramine or other agents that may interfere with enterohepatic recirculation or bind bile acids (e.g., activated charcoal).

References
1	Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.