Drug General Information (ID: DDIPG3T5SV)
Drug Name			Probenecid		Drug Info		Bismuth subsalicylate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Uricosuric Agents				Antidiarrheals
Structure

Mechanism of Probenecid-Bismuth subsalicylate Interaction (Severity Level: Moderate)
Antagonize the effect of uricosuric agents Click to Show/Hide Mechanism Graph
Drug Name		Probenecid				Bismuth subsalicylate
Mechanism		Uricosuric effects				Anti-uricosuric effects
Key Mechanism Factor 1
		Factor Name		Uricosuric agents
		Factor Description		The beneficial effects of uricosuric agents may be reduced, leading to an increased risk of hyperuricemia and gout.
Mechanism Description		Antagonize the effect of Probenecid when combined with Bismuth subsalicylate

Recommended Action
Management		Large doses of salicylates should be avoided in patients who require probenecid for the treatment of hyperuricemia or gout. However, occasional use of low dosages for analgesia or daily use of cardioprotective dosages should generally not be a concern.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Diamond JS, Paolino JS "Evidence for a postsecretory reabsorptive site for uric acid in man." J Clin Invest 52 (1973): 1491-9. [PMID: 4703233]
3	Harris M, Bryant LR, Danaher P, Alloway J "Effect of low dose daily aspirin on serum urate levels and urinary excretion in patients receiving probenecid for gouty arthritis." J Rheumatol 27 (2000): 2873-6. [PMID: 11128679]
4	Regal RE "Aspirin and uricosurics: interaction revisited." Drug Intell Clin Pharm 21 (1987): 219-20. [PMID: 3829916]