Details of Drug

Drug General Information (ID: D0187)
Drug Name	Bismuth subsalicylate
Drug Type	Small molecule
Drug Synonymous	BISMUTH SUBSALICYLATE; 14882-18-9; Bismuth oxysalicylate; Bismuth oxide salicylate; Wismutsubsalicylat; 4H-1,3,2-Benzodioxabismin-4-one, 2-hydroxy-; Basic bismuth salicylate; Bismuthi subsalicylas; Bismutum subsalicylicum; Bismuth(III) subsalicylate; pink bismuth; Stabisol; Vismut; Spiromak forte; NCGC00166299-01; Trigastronol; 2-Hydroxy-benzo[1,3,2]dioxabismin-4-one; C7H5BiO4; Bismuth oxysalicylate;Bismuth(III) salicylate basic; 2-hydroxy-2H,4H-benzo[d]1,3-dioxa-2-bismacyclohexan-4-one; Bismuth salicylate, basic; Wismutsalicylat, basisches; Bismuth, oxo(salicylato)-; Bismogenol tosse inj; CCRIS 4751; HSDB 332; Salicylic acid basic bismuth salt; Salicylic acid, bismuth basic salt; EINECS 238-953-1; Bismuth, (2-hydroxybenzoato-O1,O2)oxo-; Bismuth, (2-hydroxybenzoato-O(1),O(2))oxo-; Wismutoxidsalicylat; 2-Hydroxybenzoic acid bismuth (3+) salt, basic; bismuth-subsalicylate; MFCD00085368; Pepto-bismol (TN); Bismuth subsalicylate [USAN:USP:JAN]; (2-Hydroxybenzoato-O(sup 1))-oxobismuth; DSSTox_CID_4622; 2-Hydroxy-4H-1,3,2-benzodioxabismin-4-one; EC 238-953-1; DSSTox_RID_77471; DSSTox_GSID_24622; Bismuth subsalicylate [USAN); MLS000069654; DTXSID6024622; Bismuth subsalicylate (JAN/USP); CHEBI:261649; HMS2093H13; Pharmakon1600-01505412; HY-B0550; Tox21_112398; NSC759117; AKOS015888405; CCG-213424; DB01294; NSC 759117; NSC-759117; NCGC00166299-03; 2-hydroxy-1,3,2-benzodioxabismin-4-one; AS-65783; SMR000059234; SBI-0206855.P001; CAS-14882-18-9; V1775; C07870; D00728; AB00489978_02; Bismuth, (2-hydroxybenzoato-O1,O2)oxo- (9CI); 2-hydroxy-4H-benzo[d][1,3,2]dioxabismin-4-one; SR-05000001933; J-008518; SR-05000001933-1; Bismuth(III) subsalicylate, 99.9% trace metals basis; Bismuth(III) salicylate basic, purum, >=97.0% (KT); Bismuth subsalicylate, United States Pharmacopeia (USP) Reference Standard; 87-27-4 Click to Show/Hide
Therapeutic Class	Antidiarrheals
Structure
Structure	3D Structure		2D Structure
Formula	C7H6BiO4
InChI	InChI=1S/C7H6O3.Bi.H2O/c8-6-4-2-1-3-5(6)7(9)10;;/h1-4,8H,(H,9,10);;1H2/q;+2;/p-2
InChIKey	QBWLKDFBINPHFT-UHFFFAOYSA-L
Canonical SMILES	C1=CC=C2C(=C1)C(=O)O[Bi]O2.O
External Link
External Link	Pubchem ID	16682734

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM003 Complex formation BM013 Competitive binding of plasma proteins BM028 Competitive inhibition of renal tubular secretion BM032 Decreased renal excretion (Unspecific) BM035 Additive antimotility effects BM038 Additive CNS depression effects BM050 Increased risk of bleeding BM054 Increased risk of GI mucosal injury/bleeding risk BM064 Increased risk of hypoglycemia BM070 Increased risk of metabolic acidosis BM089 Antagonize the effect of antihypertensive agents BM099 Antagonize the effect of uricosuric agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Bismuth subsalicylate
Affected gastrointestinal absorption
	Complex formation					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1175		Omadacycline	C29H40N4O7	54697325	Moderate		Inter Info	[181], [182], [183], [184]
D1445		Sarecycline	C24H29N3O8	54681908	Moderate		Inter Info	[181], [182], [183], [184]
D0441		Demeclocycline	C21H21ClN2O8	54680690	Moderate		Inter Info	[181], [182], [183], [184]
D0530		Doxycycline	C22H24N2O8	54671203	Moderate		Inter Info	[181], [182], [183], [184]
D1070		Minocycline	C23H27N3O7	54675783	Moderate		Inter Info	[181], [182], [183], [184]
D1209		Oxytetracycline	C22H24N2O9	54675779	Moderate		Inter Info	[181], [182], [183], [184]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0012		Acetazolamide	C4H6N4O3S2	1986	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]
D0207		Brinzolamide (ophthalmic)	C12H21N3O5S3	68844	Major		Inter Info	[5], [12], [13]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Major		Inter Info	[5], [12], [13]
D0521		Dorzolamide (ophthalmic)	C10H16N2O4S3	5284549	Major		Inter Info	[5], [12], [13]
D1018		Methazolamide	C5H8N4O3S2	4100	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[194]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[198], [199], [200], [201]
D1283		Phenytoin	C15H12N2O2	1775	Minor		Inter Info	[206], [207], [208], [209], [210]
Affected excretion pathways
	Competitive inhibition of renal tubular secretion					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1025		Methotrexate	C20H22N8O5	126941	Major		Inter Info	[17], [18], [19]
	Decreased renal excretion (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[188], [189], [190]
Pharmacodynamic additive effects
	Additive antimotility effects					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[4]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[4]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[4]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[4]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[4]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[4]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[4]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[4]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[4]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[4]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[4]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[4]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[4]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[4]
	Additive CNS depression effects					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[4]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[4]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[4]
D1183		Opium	NA	NA	Moderate		Inter Info	[4]
	Increased risk of bleeding					Drug Num: 42
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[14], [15]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[16]
D0005		Abciximab	NA	NA	Moderate		Inter Info	[20], [21], [22], [23]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[128], [129], [130], [131], [132], [133], [134], [135]
D0102		Ardeparin	C26H42N2O37S5	772	Moderate		Inter Info	[128], [129], [130], [131], [132], [133], [134], [135]
D0104		Argatroban	C23H36N6O5S	92722	Moderate		Inter Info	[128], [129], [130], [131], [132], [133], [134], [135]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[128], [129], [130], [131], [132], [133], [134], [135]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[128], [129], [130], [131], [132], [133], [134], [135]
D0414		Dalteparin	C26H42N2O37S5	772	Moderate		Inter Info	[128], [129], [130], [131], [132], [133], [134], [135]
D0415		Danaparoid	NA	NA	Moderate		Inter Info	[128], [129], [130], [131], [132], [133], [134], [135]
D0447		Desirudin	C287H440N80O110S6	16129703	Moderate		Inter Info	[128], [129], [130], [131], [132], [133], [134], [135]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[136], [137], [138], [139], [3], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Moderate		Inter Info	[128], [129], [130], [131], [132], [133], [134], [135]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[136], [137], [138], [139], [3], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
D1328		Prasugrel	C20H20FNO3S	6918456	Moderate		Inter Info	[185]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[128], [129], [130], [131], [132], [133], [134], [135]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[4], [186]
D1588		Tinzaparin	C26H42N2O37S5	772	Moderate		Inter Info	[128], [129], [130], [131], [132], [133], [134], [135]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[136], [137], [138], [139], [3], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
D0189		Bivalirudin	C98H138N24O33	16129704	Moderate		Inter Info	[128], [129], [130], [131], [132], [133], [134], [135]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[136], [137], [138], [139], [3], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[136], [137], [138], [139], [3], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[21], [187]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[136], [137], [138], [139], [3], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
D0537		Drotrecogin alfa	NA	NA	Moderate		Inter Info	[128], [129], [130], [131], [132], [133], [134], [135]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[136], [137], [138], [139], [3], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
D0574		Enoxaparin	C26H42N2O37S5	772	Moderate		Inter Info	[128], [129], [130], [131], [132], [133], [134], [135]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[191], [192], [193]
D0588		Eptifibatide	C35H49N11O9S2	448812	Moderate		Inter Info	[20], [21], [22], [23]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[136], [137], [138], [139], [3], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[136], [137], [138], [139], [3], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[136], [137], [138], [139], [3], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[136], [137], [138], [139], [3], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
D0753		Heparin	C26H42N2O37S5	772	Moderate		Inter Info	[128], [129], [130], [131], [132], [133], [134], [135]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[191], [192], [193]
D0904		Lepirudin	C287H440N80O111S6	118856773	Moderate		Inter Info	[128], [129], [130], [131], [132], [133], [134], [135]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[136], [137], [138], [139], [3], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[136], [137], [138], [139], [3], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
D1593		Tirofiban	C22H36N2O5S	60947	Moderate		Inter Info	[20], [21], [22], [23]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[191], [192], [193]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[136], [137], [138], [139], [3], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[128], [129], [130], [131], [132], [133], [134], [135]
	Increased risk of GI mucosal injury/bleeding risk					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[205]
	Increased risk of hypoglycemia					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[31], [88], [105]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[31], [88], [105]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [174], [35], [36], [37], [38], [39], [40], [41], [42], [44], [45], [46], [48], [49], [50], [51], [53], [54], [55], [57], [59], [60], [61], [62], [63], [64], [65], [66], [67], [69], [72], [74], [75], [76], [79], [80], [82], [83], [84], [86], [175], [88], [176], [177], [93], [178], [179], [99], [101], [102], [103], [105], [107], [109], [111], [112], [116], [117], [118], [119], [180], [120], [121], [123], [124]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [174], [35], [36], [37], [38], [39], [40], [41], [42], [44], [45], [46], [48], [49], [50], [51], [53], [54], [55], [57], [59], [60], [61], [62], [63], [64], [65], [66], [67], [69], [72], [74], [75], [76], [79], [80], [82], [83], [84], [86], [175], [88], [176], [177], [93], [178], [179], [99], [101], [102], [103], [105], [107], [109], [111], [112], [116], [117], [118], [119], [180], [120], [121], [123], [124]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [174], [35], [36], [37], [38], [39], [40], [41], [42], [44], [45], [46], [48], [49], [50], [51], [53], [54], [55], [57], [59], [60], [61], [62], [63], [64], [65], [66], [67], [69], [72], [74], [75], [76], [79], [80], [82], [83], [84], [86], [175], [88], [176], [177], [93], [178], [179], [99], [101], [102], [103], [105], [107], [109], [111], [112], [116], [117], [118], [119], [180], [120], [121], [123], [124]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [174], [35], [36], [37], [38], [39], [40], [41], [42], [44], [45], [46], [48], [49], [50], [51], [53], [54], [55], [57], [59], [60], [61], [62], [63], [64], [65], [66], [67], [69], [72], [74], [75], [76], [79], [80], [82], [83], [84], [86], [175], [88], [176], [177], [93], [178], [179], [99], [101], [102], [103], [105], [107], [109], [111], [112], [116], [117], [118], [119], [180], [120], [121], [123], [124]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[31], [88], [105]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[31], [88], [105]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[31], [88], [105]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[31], [88], [105]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[31], [88], [105]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[31], [88], [105]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [174], [35], [36], [37], [38], [39], [40], [41], [42], [44], [45], [46], [48], [49], [50], [51], [53], [54], [55], [57], [59], [60], [61], [62], [63], [64], [65], [66], [67], [69], [72], [74], [75], [76], [79], [80], [82], [83], [84], [86], [175], [88], [176], [177], [93], [178], [179], [99], [101], [102], [103], [105], [107], [109], [111], [112], [116], [117], [118], [119], [180], [120], [121], [123], [124]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[31], [88], [105]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[125], [126], [127]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[125], [126], [127]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[125], [126], [127]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[125], [126], [127]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[125], [126], [127]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[125], [126], [127]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[125], [126], [127]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[125], [126], [127]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[125], [126], [127]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[125], [126], [127]
	Antagonize the effect of uricosuric agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1341		Probenecid	C13H19NO4S	4911	Moderate		Inter Info	[4], [195], [196], [197]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0217		Bumetanide	C17H20N2O5S	2471	Minor		Inter Info	[202], [203], [204]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Minor		Inter Info	[202], [203], [204]
D0704		Furosemide	C12H11ClN2O5S	3440	Minor		Inter Info	[202], [203], [204]
D1611		Torasemide	C16H20N4O3S	41781	Minor		Inter Info	[202], [203], [204]

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