Drug General Information (ID: DDIOA7GUXR)
Drug Name			Morphine		Drug Info		Bismuth subsalicylate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Antidiarrheals
Structure

Mechanism of Morphine-Bismuth subsalicylate Interaction (Severity Level: Moderate)
Additive antimotility effects Click to Show/Hide Mechanism Graph
Drug Name		Morphine				Bismuth subsalicylate
Mechanism 1		Decrease gastrointestinal motility				Antidiarrheal agents
Key Mechanism Factor 1
		Factor Name		Antimotility effects
		Factor Description		Antimotility drugs reduce bowel movements and increase contractions of intestinal segments for treatment of acute diarrhea. Excessive inhibition of intestinal motility can cause bloating and flatulence, increase abdominal cramps, and cause constipation at various times after treatment.
Mechanism Description		Additive antimotility effects by the combination of Morphine and Bismuth subsalicylate
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Morphine				Bismuth subsalicylate
Mechanism 2		CNS depression effects				CNS depression effects
Key Mechanism Factor 2
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Morphine and Bismuth subsalicylate

Recommended Action
Management		If concomitant use cannot be avoided, patients should be monitored for potentially excessive or prolonged CNS depression and constipation.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".