Drug General Information (ID: DDIA2QEFY6)
Drug Name			Temazepam		Drug Info		Probenecid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anxiolytics/Sedatives/Hypnotics				Uricosuric Agents
Structure

Mechanism of Temazepam-Probenecid Interaction (Severity Level: Minor)
Decreased metabolism (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Temazepam				Probenecid
Mechanism 1		Benzodiazepines				Interference with hepatic benzodiazepines conjugation
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased metabolism of Temazepam caused by Probenecid
Mechanism 2		Benzodiazepine				Interference with hepatic benzodiazepines conjugation
Key Mechanism Factor 2
		Factor Name		Pharmacokinetics
		Factor Description		Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased metabolism of Temazepam caused by Probenecid

References
1	Abernethy DR, Greenblatt DJ, Ameer B, Shader RI "Probenecid impairment of acetaminophen and lorazepam clearance: direct inhibition of ether glucuronide formation." J Pharmacol Exp Ther 234 (1985): 345-9. [PMID: 4020675]
2	Dundee JW, Halliday NJ, McMurray TJ "Aspirin and probenecid pretreatment influences the potency of thiopentone and the onset of action of midazolam." Eur J Anaesthesiol 3 (1986): 247-51. [PMID: 3780693]