Drug General Information (ID: DDIDYBXSLW)
Drug Name			Diflunisal		Drug Info		Probenecid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Uricosuric Agents
Structure

Mechanism of Diflunisal-Probenecid Interaction (Severity Level: Minor)
Competitive binding of plasma proteins Click to Show/Hide Mechanism Graph
Drug Name		Diflunisal				Probenecid
Mechanism		Competition for plasma protein binding sites				Competition for plasma protein binding sites
Key Mechanism Factor 1
		Factor Name		Plasma protein binding
		Factor Description		Plasma protein binding refers to the degree of binding of a drug to proteins in the blood, and the lower the degree of binding, the more efficiently the drug can cross cell membranes or diffuse. Plasma protein binding alters the distribution and therapeutic characteristics of the drugs.
Mechanism Description		Increased plasma concentration of Probenecid and Diflunisal due to competitive binding of plasma proteins

References
1	Diamond JS, Paolino JS "Evidence for a postsecretory reabsorptive site for uric acid in man." J Clin Invest 52 (1973): 1491-9. [PMID: 4703233]
2	Macdonald JI, Wallace SM, Herman RJ, Verbeeck RK "Effect of propenecid on the formation and elimination kinetics of the sulphate and glucuronide conjugates of diflunisal." Eur J Clin Pharmacol 47 (1995): 519-23. [PMID: 7768255]
3	Regal RE "Aspirin and uricosurics: interaction revisited." Drug Intell Clin Pharm 21 (1987): 219-20. [PMID: 3829916]