Drug General Information (ID: DDIQL1VW3Y)
Drug Name			Probenecid		Drug Info		Cefuroxime		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Uricosuric Agents				Antibiotics
Structure

Mechanism of Probenecid-Cefuroxime Interaction (Severity Level: Moderate)
Competitive inhibition of renal tubular secretion Click to Show/Hide Mechanism Graph
Drug Name		Probenecid				Cefuroxime
Mechanism		Competitive inhibition of renal tubular secretion of some cephalosporins				Cephalosporins
Key Mechanism Factor 1
		Factor Name		Renal tubular secretion
		Factor Description		Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion.
Mechanism Description		Decreased elimination of Cefuroxime caused by Probenecid mediated competitive inhibition of renal tubular secretion

Recommended Action
Management		Although probenecid has been used therapeutically to enhance serum levels of various beta-lactam antibiotics, the potential for increased adverse effects should be considered when probenecid is added to existing cephalosporin therapy, particularly when the latter is given at high dosages or to patients who are elderly or have renal dysfunction. Adjustment of the cephalosporin dosage may be required in accordance with the individual product labeling. For example, cefotaxime dosage should generally not exceed 6 grams/day when administered with probenecid. Probenecid reportedly does not affect the elimination of ceftazidime or ceftriaxone.

References
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16	Product Information. Ceftin (cefuroxime). Glaxo Wellcome, Research Triangle Park, NC.
17	Product Information. Fortaz (ceftazidime). Glaxo Wellcome, Research Triangle Park, NC.
18	Product Information. Omnicef (cefdinir). Parke-Davis, Morris Plains, NJ.
19	Product Information. Rocephin (ceftriaxone). Roche Laboratories, Nutley, NJ.
20	Product Information. Tazicef (ceftazidime). SmithKline Beecham, Philadelphia, PA.
21	Product Information. Vantin (cefpodoxime proxetil). Pharmacia and Upjohn, Kalamazoo, MI.
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