Details of Drug

Drug General Information (ID: D0329)
Drug Name	Cholestyramine
Drug Type	Small molecule
Drug Synonymous	Cholestyramine; CHOLESTYRAMINE RESIN; 11041-12-6; Azane;2-methylbutane;trimethyl-[[4-(5-phenylhexan-3-yl)phenyl]methyl]azanium;chloride Click to Show/Hide
Therapeutic Class	Bile Acid Sequestrants
Structure
Structure	3D Structure		2D Structure
Formula	C27H47ClN2
InChI	InChI=1S/C22H32N.C5H12.ClH.H3N/c1-6-20(16-18(2)21-10-8-7-9-11-21)22-14-12-19(13-15-22)17-23(3,4)5;1-4-5(2)3;;/h7-15,18,20H,6,16-17H2,1-5H3;5H,4H2,1-3H3;1H;1H3/q+1;;;/p-1
InChIKey	POJQWPZVKOFVHS-UHFFFAOYSA-M
Canonical SMILES	CCC(C)C.CCC(CC(C)C1=CC=CC=C1)C2=CC=C(C=C2)C[N+](C)(C)C.N.[Cl-]
External Link
	Pubchem ID	137699107
	TTD ID	D06ZYM

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption BM003 Complex formation BM008 Altered Fat-soluble drugs absorption BM009 Altered absorption (Unspecific)
Relation Graph

Full list of drugs interacting with Cholestyramine
Affected gastrointestinal absorption
	Complex formation					Drug Num: 79
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[1]
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Major		Inter Info	[2]
D1095		Mycophenolic acid	C17H20O6	446541	Major		Inter Info	[2]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[3], [4]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[5], [6], [7], [8], [4], [9], [10]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[11]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[12], [13], [14], [4]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[12], [13], [14], [4]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[15], [16], [17], [4], [18]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[19], [17]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[24], [25], [11]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[12], [13], [14], [4]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[3], [4]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[12], [13], [14], [4]
D0310		Chenodeoxycholic acid	C24H40O4	10133	Moderate		Inter Info	[26], [4], [18]
D0330		Cholic Acid	C24H40O5	221493	Moderate		Inter Info	[27]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[28]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[15], [16], [17], [4], [18]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[29], [30], [20], [31], [32], [4], [33]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[31], [4], [33]
D0643		Fenofibric acid	C17H15ClO4	64929	Moderate		Inter Info	[34], [35], [36]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[41]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[29], [30], [20], [31], [32], [4], [33]
D1160		Obeticholic acid	C26H44O4	447715	Moderate		Inter Info	[42]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[29], [30], [20], [31], [32], [4], [33]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[1]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[29], [30], [20], [31], [32], [4], [33]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[15], [16], [17], [4], [18]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[7], [4], [10]
D0487		Diethylstilbestrol	C18H20O2	448537	Moderate		Inter Info	[29], [30], [20], [31], [32], [4], [33]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[43], [44], [45], [4], [46], [47]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[29], [30], [20], [31], [32], [4], [33]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[29], [30], [20], [31], [32], [4], [33]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[19], [17]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[31], [4], [33]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[29], [30], [20], [31], [32], [4], [33]
D0642		Fenofibrate	C20H21ClO4	3339	Moderate		Inter Info	[34], [35], [36]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[15], [16], [17], [4], [18]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[11]
D0688		Folic acid	C19H19N7O6	135398658	Moderate		Inter Info	[29], [1]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[19], [17]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[3], [4]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[3], [4]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[3], [4]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[12], [13], [14], [4]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[15], [16], [17], [4], [18]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[12], [13], [14], [4]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[12], [13], [14], [4]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[29], [30], [20], [31], [32], [4], [33]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[31], [4], [33]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[31], [4], [33]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[15], [16], [17], [4], [18]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[12], [13], [14], [4]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[31], [4], [33]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[12], [13], [14], [4]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[11]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[15], [16], [17], [4], [18]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[15], [16], [17], [4], [18]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[29], [30], [20], [31], [32], [4], [33]
D1376		Raloxifene	C28H27NO4S	5035	Moderate		Inter Info	[51]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[11]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[3], [4]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[3], [4]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[15], [16], [17], [4], [18]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[12], [13], [14], [4]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[1], [52], [53]
D1680		Vancomycin	C66H75Cl2N9O24	14969	Moderate		Inter Info	[20], [1]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[5], [6], [7], [8], [4], [9], [10]
D0011		Acetaminophen	C8H9NO2	1983	Minor		Inter Info	[4]
D1826		Iopanoic acid	C11H12I3NO2	3735	Minor		Inter Info	[56]
D0835		Iopodic acid	C12H13I3N2O2	5241	Minor		Inter Info	[56]
D1915		Tyropanoic acid	C15H18I3NO3	5611	Minor		Inter Info	[56]
D0947		Loperamide	C29H33ClN2O2	3955	Minor		Inter Info	[57]
D0995		Meloxicam	C14H13N3O4S2	54677470	Minor		Inter Info	[58], [59]
D1109		Naproxen	C14H14O3	156391	Minor		Inter Info	[34], [20], [1], [60]
D1265		Phenobarbital	C12H12N2O3	4763	Minor		Inter Info	[4]
D1300		Piroxicam	C15H13N3O4S	54676228	Minor		Inter Info	[58], [59]
D1520		Sulindac	C20H17FO3S	1548887	Minor		Inter Info	[61]
D1564		Tetracycline	C22H24N2O8	54675776	Minor		Inter Info	[4]
	Altered Fat-soluble drugs absorption					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0233		Calcifediol	C27H44O2	5283731	Moderate		Inter Info	[20], [1], [21], [22], [23], [18]
D0234		Calcitriol	C27H44O3	5280453	Moderate		Inter Info	[20], [1], [21], [22], [23], [18]
D0527		Doxercalciferol	C28H44O2	5281107	Moderate		Inter Info	[20], [1], [21], [22], [23], [18]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[37], [38], [39], [4], [40]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[37], [38], [39]
D0495		Dihydrotachysterol	C28H46O	5311071	Moderate		Inter Info	[20], [1], [21], [22], [23], [18]
D0591		Ergocalciferol	C28H44O	5280793	Moderate		Inter Info	[20], [1], [21], [22], [23], [18]
D0715		Gemfibrozil	C15H22O3	3463	Moderate		Inter Info	[34], [20], [1], [48], [49]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[37], [38], [39], [4], [40]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[37], [38], [39], [4], [40]
D1226		Paricalcitol	C27H44O3	5281104	Moderate		Inter Info	[20], [1], [21], [22], [23], [18]
D1284		Phylloquinone	C31H46O2	5284607	Moderate		Inter Info	[50], [5], [8]
D1702		Vitamin A	C20H30O	445354	Moderate		Inter Info	[20], [1], [21], [22], [23], [18]
D1703		Vitamin E	C29H50O2	14985	Moderate		Inter Info	[20], [1], [21], [22], [23], [18]
	Altered absorption (Unspecific)					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0068		Amitriptyline	C20H23N	2160	Minor		Inter Info	[54], [20], [1], [55]
D0072		Amoxapine	C17H16ClN3O	2170	Minor		Inter Info	[54], [20], [1], [55]
D0361		Clomipramine	C19H23ClN2	2801	Minor		Inter Info	[54], [20], [1], [55]
D0446		Desipramine	C18H22N2	2995	Minor		Inter Info	[54], [20], [1], [55]
D0525		Doxepin	C19H21NO	667477	Minor		Inter Info	[54], [20], [1], [55]
D0795		Imipramine	C19H24N2	3696	Minor		Inter Info	[54], [20], [1], [55]
D1158		Nortriptyline	C19H21N	4543	Minor		Inter Info	[54], [20], [1], [55]
D1361		Protriptyline	C19H21N	4976	Minor		Inter Info	[54], [20], [1], [55]
D1647		Trimipramine	C20H26N2	5584	Minor		Inter Info	[54], [20], [1], [55]

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