Drug General Information (ID: DDIGVT3ZBC)
Drug Name			Chlorpropamide		Drug Info		Cholestyramine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidiabetic Agents				Bile Acid Sequestrants
Structure

Mechanism of Chlorpropamide-Cholestyramine Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Chlorpropamide				Cholestyramine
Mechanism		Binds to anion exchange resin/polymer				Anion exchange resin/polymer
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Cholestyramine due to formation of complexes caused by Chlorpropamide

Recommended Action
Management		Sulfonylureas should be administered at least one hour before or four to six hours after cholestyramine. Patients receiving this combination should be advised to closely monitor their blood sugar and to notify their physician if loss of control occurs.

References
1	Kivisto KT, Neuvonen PJ "The effect of cholestyramine and activated charcoal on glipizide absorption." Br J Clin Pharmacol 30 (1990): 733-6. [PMID: 2271372]
2	Product Information. Questran (cholestyramine). Par Pharmaceutical Inc, Chestnut Ridge, NY.