Drug General Information (ID: DDIH0AN3Y5)
Drug Name			Cholestyramine		Drug Info		Lomitapide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Bile Acid Sequestrants				Antihyperammonia Agents
Structure

Mechanism of Cholestyramine-Lomitapide Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Cholestyramine				Lomitapide
Mechanism		Anion exchange resin/polymer				Binds to anion exchange resin/polymer
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Cholestyramine due to formation of complexes caused by Lomitapide

Recommended Action
Management		Since bile acid sequestrants can interfere with the absorption of oral medications, administration of lomitapide and bile acid sequestrants should be separated by at least 4 hours.

References
1	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.