| Mechanism of Phenobarbital-Cholestyramine Interaction
(Severity Level: Minor)
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Complex formation
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| Drug Name |
Phenobarbital |
Cholestyramine |
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Mechanism
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Binds to anion exchange resin/polymer |
Anion exchange resin/polymer |
| Key Mechanism Factor 1 |
| Factor Name |
Chelation |
| Factor Description |
Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption. |
| Mechanism Description |
- Decreased absorption of Cholestyramine due to formation of complexes caused by Phenobarbital
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