Details of Drug-Drug Interaction
| Drug General Information (ID: DDI2FD7P4G) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Atorvastatin | Drug Info | Cholestyramine | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Statins/Antihyperlipidemic Agents | Bile Acid Sequestrants | |||||||
| Structure | |||||||||
| Mechanism of Atorvastatin-Cholestyramine Interaction (Severity Level: Moderate) | |||||||||
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| Complex formation Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Atorvastatin | Cholestyramine | |||||||
| Mechanism | Binds to anion exchange resin/polymer | Anion exchange resin/polymer | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Chelation | ||||||||
| Factor Description | Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | If therapy with both agents is necessary, the HMG-CoA reductase inhibitor should be administered at least 4 hours after the bile acid sequestrant. | ||||||||
| References | |||||||||||||||||||
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| 1 | Smith HT, Jokubaitis LA, Troendle AJ, Hwang DS, Robinson WT "Pharmacokinetics of fluvastatin and specific drug interactions." Am J Hypertens 6 (1993): s375-82. [PMID: 8297546] | ||||||||||||||||||