Drug General Information (ID: DDIB8N942I)
Drug Name			Loperamide		Drug Info		Cholestyramine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidiarrheals				Bile Acid Sequestrants
Structure

Mechanism of Loperamide-Cholestyramine Interaction (Severity Level: Minor)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Loperamide				Cholestyramine
Mechanism		Binds to anion exchange resin/polymer				Anion exchange resin/polymer
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Cholestyramine due to formation of complexes caused by Loperamide

References
1	Ti TY, Giles HG, Sellers EM "Probable interaction of loperamide and cholestyramine." Can Med Assoc J 119 (1978): 607-8. [PMID: 709452]