Details of Drug

Drug General Information (ID: D0947)
Drug Name	Loperamide
Drug Type	Small molecule
Drug Synonymous	Ioperamide; Loperacap; Loperamida; Loperamidum; Kaopectate II; Loperamide Monohydrochloride; Pepto Diarrhea Control; Apo-Loperamide; Diamide (TN); Diarr-Eze; Dimor (TN); Imodium (TN); Imodium A-D Caplets; Loperamida [INN-Spanish]; Loperamide (INN); Loperamide [INN:BAN]; Loperamidum [INN-Latin]; Lopex (TN); Maalox Anti-Diarrheal; Nu-Loperamide; PMS-Loperamide; Pepto (TN); R-18553; Rho-Loperamide Click to Show/Hide
Disease Class	ME05: Bowel habit change
Therapeutic Class	Antidiarrheals
Structure
Structure	3D Structure		2D Structure
Formula	C29H33ClN2O2
InChI	1S/C29H33ClN2O2/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3
InChIKey	RDOIQAHITMMDAJ-UHFFFAOYSA-N
Canonical SMILES	CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4
External Link
	Pubchem ID	3955
	CAS Number	53179-11-6
	CHEBI ID	6532
	TTD ID	D0CS2F
	VARIDT ID	DR00171

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM001 Altered gastrointestinal dynamics BM003 Complex formation BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM035 Additive antimotility effects BM038 Additive CNS depression effects BM067 Increased risk of hyponatremia BM076 Increased risk of prolong QT interval BM091 Antagonize the effect of cholinergic agents BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Loperamide
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[61]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[63], [64], [65], [6]
	Complex formation					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0329		Cholestyramine	C27H47ClN2	137699107	Minor		Inter Info	[71]
Affected cellular transport
	Transporter inhibition					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[7], [8], [1], [9], [6]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[7], [8], [1], [9], [6]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[7], [8], [1], [9], [6]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[7], [8], [1], [9], [6]
D0665		Flibanserin	C20H21F3N4O	6918248	Major		Inter Info	[7], [8], [1], [9], [6]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[7], [8], [1], [9], [6]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[7], [8], [9], [6]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[7], [8], [1], [9], [6]
D1372		Quinine	C20H24N2O2	3034034	Major		Inter Info	[7], [8], [9], [6]
D1501		Spironolactone	C24H32O4S	5833	Major		Inter Info	[7], [8], [1], [9], [6]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[7], [8], [1], [9], [6]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[23], [37], [38]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[39]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[23], [40]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[51]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[23], [56]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[23]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[58]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Moderate		Inter Info	[59]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[60]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[62]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[49], [23], [66], [67]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[68]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 27
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0337		Cimetidine	C10H16N6S	2756	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0364		Clopidogrel	C16H16ClNO2S	60606	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0007		Abiraterone	C24H31NO	132971	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0715		Gemfibrozil	C15H22O3	3463	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[10], [6]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1381		Ranitidine	C13H22N4O3S	3001055	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1382		Ranitidine (bismuth citrate)	C13H22N4O3S	3001055	Major		Inter Info	[1], [4], [5]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[55]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[57]
	CYP450 enzyme induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[48], [49], [23], [50]
Pharmacodynamic additive effects
	Additive antimotility effects					Drug Num: 77
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[19]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[19]
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[19]
D0135		Azatadine	C20H22N2	19861	Moderate		Inter Info	[19]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[19], [20], [21]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[19]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[19]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[19]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[19]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[19]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[19]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[19]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[23]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[19]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[19]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[19]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[23]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[19]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[19]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[19]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[19]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[19]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[19]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[19]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[19]
D0020		Acrivastine	C22H24N2O2	5284514	Moderate		Inter Info	[19]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[19]
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[19]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[19]
D0316		Chlorcyclizine	C18H21ClN2	2710	Moderate		Inter Info	[19]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[19]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[19]
D0397		Cyclizine	C18H22N2	6726	Moderate		Inter Info	[19]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[19]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[19]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[19], [20], [21]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[19]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[19], [20], [21]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[19]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[19]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[19], [20], [21]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[19]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[19]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[19]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[19]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[19]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[19]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[19]
D1264		Phenindamine	C19H19N	11291	Moderate		Inter Info	[19]
D1282		Phenyltoloxamine	C17H21NO	7077	Moderate		Inter Info	[19], [20], [21]
D1343		Procainamide	C13H21N3O	4913	Moderate		Inter Info	[19]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[19]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[19]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[19]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[19]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[19]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[19]
D0987		Meclizine	C25H27ClN2	4034	Moderate		Inter Info	[19]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[19]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[19]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[19]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[19]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[19]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[19]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[19]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[19]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[19]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[19]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[19]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[19]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[19]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[19]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[19]
D1649		Tripelennamine	C16H21N3	5587	Moderate		Inter Info	[19]
D1650		Triprolidine	C19H22N2	5282443	Moderate		Inter Info	[19]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[19]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[19]
	Additive CNS depression effects					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[22], [23], [24]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[22], [23], [24]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[23]
D0305		Cetirizine	C21H25ClN2O3	2678	Moderate		Inter Info	[25], [26]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[23]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[22], [23], [24]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[23]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[36]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[23]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[49], [52]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[21], [53], [54], [23], [20]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[23]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[23]
D0917		Levocetirizine	C21H25ClN2O3	1549000	Moderate		Inter Info	[25], [26]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[23]
D1183		Opium	NA	NA	Moderate		Inter Info	[23]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[23]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[23]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[23]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Moderate		Inter Info	[23]
D1172		Olopatadine (nasal)	C21H23NO3	5281071	Moderate		Inter Info	[21], [69], [20]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[23]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[23]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[70]
	Increased risk of hyponatremia					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0449		Desmopressin	C46H64N14O12S2	5311065	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35]
	Increased risk of prolong QT interval					Drug Num: 125
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18]
D0003		Abarelix	C72H95ClN14O14	16131215	Moderate		Inter Info	[1], [6]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[1], [6]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[1], [6]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[1], [6]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[1], [6]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[1], [6]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[1], [6]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[1], [6]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[1], [6]
D0342		Cisapride	C23H29ClFN3O4	6917698	Moderate		Inter Info	[1], [6]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[1], [6]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[1], [6]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[1], [20], [6]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[1], [6]
D0514		Dolasetron	C19H20N2O3	3033818	Moderate		Inter Info	[1], [6]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[1], [6]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[1], [6]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[1], [6]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[1], [6]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[1], [6]
D0682		Flutamide	C11H11F3N2O3	3397	Moderate		Inter Info	[1], [6]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[1], [6]
D0787		Ibutilide	C20H36N2O3S	60753	Moderate		Inter Info	[1], [6]
D0908		Leuprolide	C59H84N16O12	657181	Moderate		Inter Info	[1], [6]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[1], [20], [6]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[1], [6]
D0107		Arsenic trioxide	As2O3	14888	Moderate		Inter Info	[1], [6]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[1], [6]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[1], [6]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[1], [6]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[1], [6]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[1], [6]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[1], [6]
D0358		Clofazimine	C27H22Cl2N4	2794	Moderate		Inter Info	[1], [6]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[1], [6]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[1], [6]
D0437		Degarelix	C82H103ClN18O16	16136245	Moderate		Inter Info	[1], [6]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[1], [6]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[1], [6]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[1], [20], [6]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[1], [6]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[1], [6]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[1], [6]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[1], [6]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[1], [6]
D0661		Fingolimod	C19H33NO2	107970	Moderate		Inter Info	[1], [6]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[1], [6]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[1], [6]
D0712		Gatifloxacin	C19H22FN3O4	5379	Moderate		Inter Info	[1], [6]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[1], [6]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[1], [6]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[1], [6]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Moderate		Inter Info	[1], [6]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[1], [6]
D0758		Histrelin	C66H86N18O12	25077993	Moderate		Inter Info	[1], [6]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[1], [6]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[1], [6]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[1], [6]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[1], [6]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[1], [6]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[1], [6]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Moderate		Inter Info	[1], [6]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[1], [6]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[1], [6]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[1], [20], [6]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[1], [6]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[1], [6]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Moderate		Inter Info	[1], [20], [6]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[1], [6]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[1], [6]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[1], [6]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[1], [6]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[1], [6]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[1], [6]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[1], [6]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[1], [6]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[1], [6]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[1], [6]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[1], [6]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[1], [6]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[1], [6]
D1230		Pasireotide	C58H66N10O9	9941444	Moderate		Inter Info	[1], [6]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[1], [6]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[1], [6]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[1], [6]
D1339		Primaquine	C15H21N3O	4908	Moderate		Inter Info	[1], [6]
D1342		Probucol	C31H48O2S2	4912	Moderate		Inter Info	[1], [6]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[1], [6]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[1], [6]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[1], [6]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[1], [6]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[1], [6]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[1], [6]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[1], [6]
D1463		Sevoflurane	C4H3F7O	5206	Moderate		Inter Info	[1], [6]
D1474		Siponimod	C29H35F3N2O3	44599207	Moderate		Inter Info	[1], [6]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Moderate		Inter Info	[1], [6]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[1], [6]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[1], [6]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[1], [6]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[1], [6]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Moderate		Inter Info	[1], [6]
D1651		Triptorelin	C64H82N18O13	25074470	Moderate		Inter Info	[1], [6]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[1], [6]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Moderate		Inter Info	[1], [6]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[1], [6]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[1], [6]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[1], [6]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[1], [6]
D1092		Moxifloxacin	C21H24FN3O4	152946	Moderate		Inter Info	[1], [6]
D1137		Nilutamide	C12H10F3N3O4	4493	Moderate		Inter Info	[1], [6]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[1], [6]
D1216		Palonosetron	C19H24N2O	6337614	Moderate		Inter Info	[1], [6]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[1], [6]
D1254		Perflutren	C3F8	6432	Moderate		Inter Info	[1], [6]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[1], [6]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[1], [6]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[1], [6]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[1], [6]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[1], [6]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[1], [6]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[1], [6]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[1], [6]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[1], [6]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0562		Eluxadoline	C32H35N5O5	11250029	Moderate		Inter Info	[23], [47]
Pharmacodynamic antagonistic effects
	Antagonize the effect of cholinergic agents					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[41], [42], [43], [44], [45], [46]
D1285		Physostigmine	C15H21N3O2	5983	Moderate		Inter Info	[41], [42], [43], [44], [45], [46]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[41], [42], [43], [44], [45], [46]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[41], [42], [43], [44], [45], [46]

References
1	Eggleston W, Clark KH, Marraffa JM "Loperamide abuse associated with cardiac dysrhythmia and death." Ann Emerg Med 69 (2017): 83-6. [PMID: 27140747]
2	Kim KA, Chung J, Jung DH, Park JY "Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes." Eur J Clin Pharmacol 60 (2004): 575-81. [PMID: 15365656]
3	Niemi M, Tornio A, Pasanen MK, Fredrikson H, Neuvonen PJ, Backman JT "Itraconazole, gemfibrozil and their combination markedly raise the plasma concentrations of loperamide." Eur J Clin Pharmacol 62 (2006): 463-72. [PMID: 16758263]
4	Product Information. Imodium (loperamide). Janssen Pharmaceutica, Titusville, NJ.
5	Tayrouz Y, Ganssmann B, Ding R, et al. "Ritonavir increases loperamide plasma concentrations without evidence for P-glycoprotein involvement." Clin Pharmacol Ther 70 (2001): 405-14. [PMID: 11719726]
6	US Food and Drug Administration "FDA warns about serious heart problems with high doses of the antidiarrheal medicine loperamide (Imodium), including from abuse and misuse.".
7	Adachi Y, Suzuki H, Sugiyama Y "Quantitative evaluation of the function of small intestinal P-glycoprotein: comparative studies between in Situ and in Vivo." Pharm Res 20 (2003): 1163-9. [PMID: 12948013]
8	Crowe A, Wong P "Potential roles of P-gp and calcium channels in loperamide and diphenoxylate transport." Toxicol Appl Pharmacol 193 (2003): 127-37. [PMID: 14613723]
9	Sadeque AJ, Wandel C, He H, Shah S, Wood AJ "Increased drug delivery to the brain by P-glycoprotein inhibition." Clin Pharmacol Ther 68 (2000): 231-7. [PMID: 11014404]
10	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
11	Goto M, Sato M, Kitzazawa H, et.al "Papaverine-induced QT interval prolongation and ventricular fibrillation in a patient with a history of drug-induced QT prolongation." Intern Med 53 (2014): 1629-31. [PMID: 25088875]
12	Inoue T, Asahi S, Takayanagi K, Morooka S, Takabatake Y "QT prolongation and possibility of ventricular arrhythmias after intracoronary papaverine." Cardiology 84 (1994): 9-13. [PMID: 7511988]
13	Jain A, Jenkins MG "Intracoronary electrocardiogram during torsade des pointes secondary to intracoronary papaverine." Cathet Cardiovasc Diagn 18 (1989): 255-7. [PMID: 2605630]
14	Kern MJ, Deligonul U, Serota H, Gudipati C, Buckingham T "Ventricular arrhythmia due to intracoronary papaverine: analysis of QT intervals and coronary vasodilatory reserve." Cathet Cardiovasc Diagn 19 (1990): 229-36. [PMID: 2334953]
15	Nakayama M, Saito A, Kitazawa H, et.al "Papaverine-induced polymorphic ventricular tachycardia in relation to QTU and giant T-U waves in four cases." Intern Med 51 (2012): 351-6. [PMID: 22333368]
16	Nakayama M, Tanaka N, Sakoda K, et.al "Papaverine-induced polymorphic ventricular tachycardia during coronary flow reserve study of patients with moderate coronary artery disease." Circ J 79 (2015): 530-6. [PMID: 25746536]
17	Talman CL, Winniford MD, Rossen JD, Simonetti I, Kienzle MG, Marcus ML "Polymorphous ventricular tachycardia: a side effect of intracoronary papaverine." J Am Coll Cardiol 15 (1990): 275-8. [PMID: 2299067]
18	Vrolix M, Piessens J, De Geest H "Torsades de pointes after intracoronary papaverine." Eur Heart J 12 (1991): 273-6. [PMID: 2044564]
19	Eronen M, Putkonen H, Hallikainen T, Vartiainen H "Lethal gastroenteritis associated with clozapine and loperamide." Am J Psychiatry 160 (2003): 2242-2243. [PMID: 14638602]
20	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
21	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
22	Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
23	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
24	Product Information. Mirvaso (brimonidine topical). Galderma Laboratories Inc, Cranbury, NJ.
25	Product Information. Zyrtec (cetirizine). Pfizer US Pharmaceuticals, New York, NY.
26	Product Information. Xyzal (levocetirizine). UCB Pharma Inc, Smyrna, GA.
27	Sarret D, Le Berre JP, Zemraoui N "Tramadol-induced hyponatremia." Am J Kidney Dis 52 (2008): 1026 author reply 1027. [PMID: 18971023]
28	Product Information. DDAVP (desmopressin). Rhone-Poulenc Rorer, Collegeville, PA.
29	Appel WC "Possible roles of normeperidine and hyponatremia in a postoperative death." Can Med Assoc J 137 (1987): 912-3. [PMID: 3676934]
30	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
31	Canadian Pharmacists Association.
32	Kokko H, Hall PD, Afrin LB "Fentanyl-associated syndrome of inappropriate antidiuretic hormone secretion." Pharmacotherapy 22 (2002): 1188-92. [PMID: 12222557]
33	Product Information. Stimate (desmopressin). Forest Pharmaceuticals, St. Louis, MO.
34	Callreus T, Lundahl J, Hoglund P, Bengtsson P "Changes in gastrointestinal motility influence the absorption of desmopressin." Eur J Clin Pharmacol 55 (1999): 305-9. [PMID: 10424324]
35	Product Information. MS Contin (morphine). Purdue Frederick Company, Norwalk, CT.
36	Product Information. Zulresso (brexanolone). Sage Therapeutics, Inc., Cambridge, MA.
37	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
38	Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.
39	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
40	Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
41	Beers MH, Ouslander JG, Rollingher I, Reuben DB, Brooks J, Beck JC "Explicit criteria for determining inappropriate medication use in nursing home residents." Arch Intern Med 151 (1991): 1825-32. [PMID: 1888249]
42	Carnahan RM, Lund BC, Perry PJ, Chrischilles EA "The concurrent use of anticholinergics and cholinesterase inhibitors: rare event or common practice?" J Am Geriatr Soc 52 (2004): 2082-7. [PMID: 15571547]
43	Edwards KR, O'Connor JT "Risk of delirium with concomitant use of tolterodine and acetylcholinesterase inhibitors." J Am Geriatr Soc 50 (2002): 1165-6. [PMID: 12110086]
44	Fick DM, Cooper JW, Wade WE, Waller JL, Maclean JR, Beers MH "Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts." Arch Intern Med 163 (2003): 2716-2724. [PMID: 14662625]
45	Katz IR, Sands LP, Bilker W, DiFilippo S, Boyce A, D'Angelo K "Identification of medications that cause cognitive impairment in older people: the case of oxybutynin chloride." J Am Geriatr Soc 46 (1998): 8-13. [PMID: 9434659]
46	Roe CM, Anderson MJ, Spivack B "Use of anticholinergic medications by older adults with dementia." J Am Geriatr Soc 50 (2002): 836-42. [PMID: 12028169]
47	Product Information. Viberzi (eluxadoline). Actavis Pharma, Inc., Parsippany, NJ.
48	Benoist G, van Oort I, et al "Drug-drug interaction potential in men treated with enzalutamide: Mind the gap." Br J Clin Pharmacol 0 (2017): epub. [PMID: 28881501]
49	Cerner Multum, Inc. "Australian Product Information.".
50	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
51	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
52	Product Information. Spravato (esketamine). Janssen Pharmaceuticals, Titusville, NJ.
53	Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
54	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
55	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
56	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
57	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
58	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
59	Product Information. Harvoni (ledipasvir-sofosbuvir). Gilead Sciences, Foster City, CA.
60	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
61	Product Information. Symlin (pramlintide). Amphastar Pharmaceuticals Inc, South El Monte, CA.
62	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
63	John L, Marra F, Ensom MH "Role of therapeutic drug monitoring for protease inhibitors." Ann Pharmacother 35 (2001): 745-54. [PMID: 11408994]
64	Mikus G, Schmidt L, Burhenne J, et al. "Reduction of saquinavir exposure by coadministration of loperamide : a two-way pharmacokinetic interaction." Clin Pharmacokinet 43 (2004): 1015-24. [PMID: 15530130]
65	Durant J, Clevenbergh P, Garraffo R, Halfon P, Icard S, DelGiudice P, Montagne N, Schapiro JM, Dellamonica P "Importance of protease inhibitor plasma levels in HIV-infected patients treated with genotypic-guided therapy: pharmacological data from the Viradapt Study." Aids 14 (2000): 1333-9. [PMID: 10930147]
66	Product Information. Jynarque (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
67	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
68	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
69	Product Information. Patanase (olopatadine nasal). Alcon Laboratories Inc, Fort Worth, TX.
70	Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.
71	Ti TY, Giles HG, Sellers EM "Probable interaction of loperamide and cholestyramine." Can Med Assoc J 119 (1978): 607-8. [PMID: 709452]

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence