Drug General Information (ID: DDIHFVZ8PK)
Drug Name			Meclizine		Drug Info		Loperamide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiallergic Agents				Antidiarrheals
Structure

Mechanism of Meclizine-Loperamide Interaction (Severity Level: Moderate)
Additive antimotility effects Click to Show/Hide Mechanism Graph
Drug Name		Meclizine				Loperamide
Mechanism		Decrease gastrointestinal motility				Decrease gastrointestinal motility
Key Mechanism Factor 1
		Factor Name		Antimotility effects
		Factor Description		Antimotility drugs reduce bowel movements and increase contractions of intestinal segments for treatment of acute diarrhea. Excessive inhibition of intestinal motility can cause bloating and flatulence, increase abdominal cramps, and cause constipation at various times after treatment.
Mechanism Description		Additive antimotility effects by the combination of Loperamide and Meclizine

Recommended Action
Management		Until further information is available, loperamide should be used with caution in combination with drugs that possess significant anticholinergic activity (e.g., antihistamines antispasmodics neuroleptics phenothiazines skeletal muscle relaxants tricyclic antidepressants class IA antiarrhythmics especially disopyramide).

References
1	Eronen M, Putkonen H, Hallikainen T, Vartiainen H "Lethal gastroenteritis associated with clozapine and loperamide." Am J Psychiatry 160 (2003): 2242-2243. [PMID: 14638602]