Drug General Information (ID: DDIJNFY3RC)
Drug Name			Phylloquinone		Drug Info		Cholestyramine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vitamins				Bile Acid Sequestrants
Structure

Mechanism of Phylloquinone-Cholestyramine Interaction (Severity Level: Moderate)
Altered Fat-soluble drugs absorption Click to Show/Hide Mechanism Graph
Drug Name		Phylloquinone				Cholestyramine
Mechanism		Fat-soluble agent				Decrease fat-soluble agent absorption
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased absorption of Phylloquinone caused by Cholestyramine

Recommended Action
Management		If oral vitamin K is given concurrently, it should be taken at least 1 hour before or 4 to 6 hours after cholestyramine.

References
1	Acuna R, Gonzalez Ceron M "Hypoprothrombinemia and bleeding associated to treatment with cholestyramine (author's transl)." Rev Med Chil 105 (1977): 27-8. [PMID: 882747]
2	Gross L, Brotman M "Hypoprothrombinemia and hemorrhage associated with cholestyramine therapy." Ann Intern Med 72 (1970): 95-6. [PMID: 5410402]
3	Longstreth GF, Newcomer AD "Drug-induced malabsorption." Mayo Clin Proc 50 (1975): 284-93. [PMID: 1127993]