Details of Drug | MecDDI

Drug General Information (ID: D1284)
Drug Name		Phylloquinone
Drug Type		Small molecule
Drug Synonymous		Phyllochinon; Phyllohydroquinone; Phytomenadione; Fitomenadione [DCIT]; Phyllochinon [German]; LT00452032; Fitomenadiona [INN-Spanish]; Mephyton (TN); Phylloquinone (8CI); Phytomenadione (INN); Phytomenadionum [INN-Latin]; Phytonadione [USAN:JAN]; Vitamin K1 (TN); Vitamin K1 (VAN); Vitamin K1 (generic); Phythyl-menadion (GERMAN); Phytonadione (JP15/USP); 1,4-Naphthalenedione, 2-methyl-3-((2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecenyl)-, radical ion(1-); 2-(3,7,11,15-Tetramethylhexadec-2-enyl)-3-methylnaphthalene-1,4-dione; 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalened-ione; 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione; 2-Methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)-1,4-naphthoquinone; 2-Methyl-3-phythyl-1,4-naphthochinon; 2-Methyl-3-phytyl-1,4-naphthochinon; 2-Methyl-3-phytyl-1,4-naphthochinon [German]; 2-methyl-3-(3,7,11,15-tetramethylhexadec-2-en-1-yl)naphthalene-1,4-dione; 2-methyl-3-[(E)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione; 3-Phytylmenadione Click to Show/Hide
Disease Class		GA20-GA21: Bleeding disorder; 5B55-5B5F: Vitamin deficiency
Therapeutic Class		Vitamins
Structure
Structure		3D Structure				2D Structure
Formula		C31H46O2
InChI		1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1
InChIKey		MBWXNTAXLNYFJB-NKFFZRIASA-N
Canonical SMILES		CC1=C(C(=O)C2=CC=CC=C2C1=O)CC=C(C)CCCC(C)CCCC(C)CCCC(C)C
External Link
		Pubchem ID		5284607
		CAS Number		79083-00-4
		CHEBI ID		18067
		TTD ID		D00FSV

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM007 Pharmacodynamic antagonistic effects BM008 Altered Fat-soluble drugs absorption BM085 Antagonize the effect of antithrombotic agents
Relation Graph

Full list of drugs interacting with Phylloquinone
Affected gastrointestinal absorption
					Altered Fat-soluble drugs absorption																																																																Drug Num: 6
Drug ID															Drug Name															Formula															Pubchem ID															Severity Level															Interaction Detail													REF
D0381															Colesevelam															C31H67Cl3N4O															160051															Moderate															Inter Info													[1], [2], [3]
D0382															Colestipol															C11H28ClN5O															62816															Moderate															Inter Info													[1], [2], [3]
D0329															Cholestyramine															C27H47ClN2															137699107															Moderate															Inter Info													[7], [8], [9]
D1462															Sevelamer															C6H12ClNO															3085017															Moderate															Inter Info													[1], [2], [3]
D1069															Mineral oil															NA															NA															Minor															Inter Info													[10]
D1187															Orlistat															C29H53NO5															3034010															Minor															Inter Info													[11]
Pharmacodynamic antagonistic effects
					Antagonize the effect of antithrombotic agents																																																																Drug Num: 3
Drug ID															Drug Name															Formula															Pubchem ID															Severity Level															Interaction Detail													REF
D0481															Dicoumarol															C19H12O6															54676038															Moderate															Inter Info													[4], [5], [6]
D0087															Anisindione															C16H12O3															2197															Moderate															Inter Info													[4], [5], [6]
D1711															Warfarin															C19H16O4															54678486															Moderate															Inter Info													[4], [5], [6]

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Welchol (colesevelam) Daiichi Sankyo, Inc., Parsippany, NJ.
4	Howard PA, Hannaman KN "Warfarin resistance linked to enteral nutrition products." J Am Diet Assoc 85 (1985): 713-5. [PMID: 3998343]
5	Kempin SJ "Warfarin resistance caused by broccoli." N Engl J Med 308 (1983): 1229-30. [PMID: 6843604]
6	Lee M, Schwartz RN, Sharifi R "Warfarin resistance and vitamin K." Ann Intern Med 94 (1981): 140-1. [PMID: 7447217]
7	Acuna R, Gonzalez Ceron M "Hypoprothrombinemia and bleeding associated to treatment with cholestyramine (author's transl)." Rev Med Chil 105 (1977): 27-8. [PMID: 882747]
8	Gross L, Brotman M "Hypoprothrombinemia and hemorrhage associated with cholestyramine therapy." Ann Intern Med 72 (1970): 95-6. [PMID: 5410402]
9	Longstreth GF, Newcomer AD "Drug-induced malabsorption." Mayo Clin Proc 50 (1975): 284-93. [PMID: 1127993]
10	Product Information. Mephyton (phytonadione). Merck &amp Co, Inc, West Point, PA.
11	Product Information. Xenical (orlistat). Roche Laboratories, Nutley, NJ.