Drug General Information (ID: DDIW5M07J3)
Drug Name			Colesevelam		Drug Info		Phylloquinone		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Bile Acid Sequestrants				Vitamins
Structure

Mechanism of Colesevelam-Phylloquinone Interaction (Severity Level: Moderate)
Altered Fat-soluble drugs absorption Click to Show/Hide Mechanism Graph
Drug Name		Colesevelam				Phylloquinone
Mechanism		Decrease fat-soluble agent absorption				Fat-soluble agent
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased absorption of Phylloquinone caused by Colesevelam

Recommended Action
Management		Oral vitamin supplements should be administered at least 4 hours before colesevelam and either 1 hour before or 4 to 6 hours after other bile acid sequestrants and sevelamer.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Welchol (colesevelam) Daiichi Sankyo, Inc., Parsippany, NJ.