Details of Drug

Drug General Information (ID: D0381)
Drug Name	Colesevelam
Drug Type	Small molecule
Drug Synonymous	CholestaGel; Welchol; Colesevelam hydrochloride; Welchol DM; GT31-104; GT31-104HB Click to Show/Hide
Disease Class	5C80: Hyper-lipoproteinaemia
Therapeutic Class	Bile Acid Sequestrants
Structure
Structure	3D Structure		2D Structure
Formula	C31H67Cl3N4O
InChI	1S/C13H27N.C12H27N2.C3H5ClO.C3H7N.2ClH/c1-3-5-6-7-8-9-10-11-13-14-12-4-2;1-5-10-13-11-8-6-7-9-12-14(2,3)4;4-1-3-2-5-3;1-2-3-4;;/h4,14H,2-3,5-13H2,1H3;5,13H,1,6-12H2,2-4H3;3H,1-2H2;2H,1,3-4H2;2*1H/q;+1;;;;/p-1
InChIKey	VTAKZNRDSPNOAU-UHFFFAOYSA-M
Canonical SMILES	CCCCCCCCCCNCC=C.C[N+](C)(C)CCCCCCNCC=C.C=CCN.C1C(O1)CCl.Cl.[Cl-]
External Link
	Pubchem ID	160051
	CAS Number	182815-44-7
	TTD ID	D01YVT

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM006 Pharmacodynamic additive effects BM003 Complex formation BM008 Altered Fat-soluble drugs absorption BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Colesevelam
Affected gastrointestinal absorption
	Complex formation					Drug Num: 61
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1095		Mycophenolic acid	C17H20O6	446541	Major		Inter Info	[3]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[1]
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Major		Inter Info	[3]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[4], [5]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[4], [5]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[4], [5]
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[4], [5]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[4], [5]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[10], [11], [12], [13], [5]
D0310		Chenodeoxycholic acid	C24H40O4	10133	Moderate		Inter Info	[14], [13], [5]
D0330		Cholic Acid	C24H40O5	221493	Moderate		Inter Info	[15]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[16]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[10], [11], [12], [13], [5]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[10], [11], [12], [13], [5]
D0485		Dienogest	C20H25NO2	68861	Moderate		Inter Info	[17], [18], [5]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[5]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[17], [18], [5]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[4], [5]
D0643		Fenofibric acid	C17H15ClO4	64929	Moderate		Inter Info	[4], [19], [20]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[4], [5]
D0705		Gabapentin	C9H17NO2	3446	Moderate		Inter Info	[4], [5]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[4], [5]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[4], [5]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[4], [5]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[4], [5], [23]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[24]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[17], [18], [5]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[10], [11], [12], [13], [5]
D1156		Norgestimate	C23H31NO3	6540478	Moderate		Inter Info	[17], [18], [5]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[5]
D1160		Obeticholic acid	C26H44O4	447715	Moderate		Inter Info	[25]
D1201		Oxtriphylline	C12H21N5O3	656652	Moderate		Inter Info	[4], [5]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[4], [5]
D1343		Procainamide	C13H21N3O	4913	Moderate		Inter Info	[4], [5]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[4], [5]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[4], [5], [23]
D1598		Tocainide	C11H16N2O	38945	Moderate		Inter Info	[4], [5]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[4], [5]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[1]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[4], [5]
D0544		Dyphylline	C10H14N4O4	3182	Moderate		Inter Info	[4], [5]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[10], [11], [12], [13], [5]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[4], [5]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[10], [11], [12], [13], [5]
D0890		Lamotrigine	C9H7Cl2N5	3878	Moderate		Inter Info	[4], [5]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[5]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[4], [5]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[4], [5]
D1054		Mexiletine	C11H17NO	4178	Moderate		Inter Info	[4], [5]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[17], [18], [5]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[4], [5]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[4], [5]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[4], [5]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[10], [11], [12], [13], [5]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[10], [11], [12], [13], [5]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[4], [5]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[4], [5]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[4], [5]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[4], [5]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[4], [5]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[10], [11], [12], [13], [5]
	Altered Fat-soluble drugs absorption					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0233		Calcifediol	C27H44O2	5283731	Moderate		Inter Info	[6], [1], [7], [8], [9], [5]
D0234		Calcitriol	C27H44O3	5280453	Moderate		Inter Info	[6], [1], [7], [8], [9], [5]
D0328		Cholecalciferol	C27H44O	5280795	Moderate		Inter Info	[6], [1], [7], [8], [9], [5]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[4], [5]
D0495		Dihydrotachysterol	C28H46O	5311071	Moderate		Inter Info	[6], [1], [7], [8], [9], [5]
D0527		Doxercalciferol	C28H44O2	5281107	Moderate		Inter Info	[6], [1], [7], [8], [9], [5]
D0715		Gemfibrozil	C15H22O3	3463	Moderate		Inter Info	[4], [6], [1], [21], [22]
D1284		Phylloquinone	C31H46O2	5284607	Moderate		Inter Info	[6], [1], [5]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[26], [4], [5]
D0591		Ergocalciferol	C28H44O	5280793	Moderate		Inter Info	[6], [1], [7], [8], [9], [5]
D1226		Paricalcitol	C27H44O3	5281104	Moderate		Inter Info	[6], [1], [7], [8], [9], [5]
D1702		Vitamin A	C20H30O	445354	Moderate		Inter Info	[6], [1], [7], [8], [9], [5]
D1703		Vitamin E	C29H50O2	14985	Moderate		Inter Info	[6], [1], [7], [8], [9], [5]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[4], [5]
Pharmacodynamic additive effects
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0178		Bexarotene	C24H28O2	82146	Major		Inter Info	[1], [2]

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Targretin (bexarotene) Ligand Pharmaceuticals, San Diego, CA.
3	Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.
4	Canadian Pharmacists Association.
5	Product Information. Welchol (colesevelam) Daiichi Sankyo, Inc., Parsippany, NJ.
6	Cerner Multum, Inc. "Australian Product Information.".
7	Peirce D, Hossack S, Poole L, et.al "The effect of sevelamer carbonate and lanthanum carbonate on the pharmacokinetics of oral calcitriol." Nephrol Dial Transplant 26 (2011): 1615-21. [PMID: 20921291]
8	Product Information. Fosamax Plus D (alendronate-cholecalciferol). Merck & Company Inc, West Point, PA.
9	Product Information. Rocaltrol (calcitriol). Roche Laboratories, Nutley, NJ.
10	Johansson C, Adamsson U, Stierner U, Lindsten T "Interaction by cholestyramine on the uptake of hydrocortisone in the gastrointestinal tract." Acta Med Scand 204 (1978): 509-12. [PMID: 735882]
11	Nekl KE, Aron DC "Hydrocortisone-colestipol interaction." Ann Pharmacother 27 (1993): 980-1. [PMID: 8364291]
12	Product Information. Colestid (colestipol HCI). Pharmacia and Upjohn, Kalamazoo, MI.
13	Product Information. Questran (cholestyramine). Par Pharmaceutical Inc, Chestnut Ridge, NY.
14	Product Information. Chenodal (chenodeoxycholic acid). Manchester Pharmaceutical, Fort Collins, CO.
15	Product Information. Cholbam (cholic acid). Manchester Pharmaceutical, Fort Collins, CO.
16	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
17	Bailey DG, Arnold JMO, Spence JD "Grapefruit juice and drugs - how significant is the interaction." Clin Pharmacokinet 26 (1994): 91-8. [PMID: 8162660]
18	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
19	Product Information. Tricor (fenofibrate). Abbott Pharmaceutical, Abbott Park, IL.
20	Product Information. Trilipix (fenofibric acid). Abbott Pharmaceutical, Abbott Park, IL.
21	Forland SC, Feng Y, Cutler RE "Apparent reduced absorption of gemfibrozil when given with colestipol." J Clin Pharmacol 30 (1990): 29-32. [PMID: 2303577]
22	Lozada A, Dujovne CA "Drug interactions with fibric acids." Pharmacol Ther 63 (1994): 163-76. [PMID: 7809177]
23	Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]
24	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
25	Product Information. Ocaliva (obeticholic acid). Intercept Pharmaceuticals, Inc., New York, NY.
26	Bodiford AB, Kessler FO, Fermo JD, Ragucci KR "Elevated international normalized ratio with the consumption of grapefruit and use of warfarin." SAGE Open Med Case Rep 0 (2013): 1-3. [PMID: 27489634]

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