Drug General Information (ID: DDI9OZASE3)
Drug Name			Glimepiride		Drug Info		Colesevelam		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidiabetic Agents				Bile Acid Sequestrants
Structure

Mechanism of Glimepiride-Colesevelam Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Glimepiride				Colesevelam
Mechanism		Binds to anion exchange resin/polymer				Anion exchange resin/polymer
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Colesevelam due to formation of complexes caused by Glimepiride

Recommended Action
Management		In general, drugs with a narrow therapeutic index as well as those that have been shown to interact with colesevelam should be administered at least 4 hours before the colesevelam dose. Clinical and laboratory monitoring of drug levels and effects should be considered.

References
1	Canadian Pharmacists Association.
2	Product Information. Welchol (colesevelam) Daiichi Sankyo, Inc., Parsippany, NJ.