Drug General Information (ID: DDIJ1ZYT53)
Drug Name			Colesevelam		Drug Info		Venetoclax		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Bile Acid Sequestrants				Antineoplastics
Structure

Mechanism of Colesevelam-Venetoclax Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Colesevelam				Venetoclax
Mechanism		Anion exchange resin/polymer				Binds to anion exchange resin/polymer
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Colesevelam due to formation of complexes caused by Venetoclax

Recommended Action
Management		If concomitant use is required, venetoclax should be administered at least 4 to 6 hours after the bile acid sequestrant. Close clinical and laboratory monitoring may be considered during coadministration, since adjusting the dosing interval may not completely prevent the interaction.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".