Drug General Information (ID: DDIB814SZW)
Drug Name			Colesevelam		Drug Info		Gemfibrozil		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Bile Acid Sequestrants				Antihyperammonia Agents
Structure

Mechanism of Colesevelam-Gemfibrozil Interaction (Severity Level: Moderate)
Altered Fat-soluble drugs absorption Click to Show/Hide Mechanism Graph
Drug Name		Colesevelam				Gemfibrozil
Mechanism		Decrease fat-soluble agent absorption				Fat-soluble agent
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased absorption of Gemfibrozil caused by Colesevelam

Recommended Action
Management		Gemfibrozil and bile acid sequestrants should be taken at least 2 hours apart.

References
1	Canadian Pharmacists Association.
2	Cerner Multum, Inc. "Australian Product Information.".
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4	Forland SC, Feng Y, Cutler RE "Apparent reduced absorption of gemfibrozil when given with colestipol." J Clin Pharmacol 30 (1990): 29-32. [PMID: 2303577]
5	Lozada A, Dujovne CA "Drug interactions with fibric acids." Pharmacol Ther 63 (1994): 163-76. [PMID: 7809177]