Details of Drug

Drug General Information (ID: D0715)
Drug Name	Gemfibrozil
Drug Type	Small molecule
Drug Synonymous	ApoGemfibrozil; Ausgem; Bolutol; Brozil; Cholespid; Clearol; Decrelip; Elmogan; Fetinor; Fibratol; Fibrocit; GFZ; Gemd; Gemfibril; Gemfibromax; Gemfibrosil; Gemfibrozilo; Gemfibrozilum; Gemhexal; Gemlipid; Gemnpid; GenGemfibrozil; Genlip; Gozid; Hidil; Hipolixan; Innogem; Innogen; Ipolipid; Jezil; Lanaterom; Lifibron; Lipazil; Lipigem; Lipira; Lipizyl; Lipozid; Lipur; Litarek; Lopid; Micolip; Normolip; NuGemfibrozil; Pilder; Polyxit; Progemzal; Reducel; Regulip; Renabrazin; Sinelip; Synbrozil; Taborcil; Tentroc; Trialmin; Alphapharm Brand of Gemfibrozil; Apo Gemfibrozil; Apotex Brand of Gemfibrozil; Bayvit Brand of Gemfibrozil; Bexal Brand of Gemfibrozil; Biochemie Brand of Gemfibrozil; Bull Brand of Gemfibrozil; Cantabria Brand of Gemfibrozil; Chem mart Brand of Gemfibrozil; Chem mart Gemfibrozil; DBL Gemfibrozil; Douglas Brand of Gemfibrozil; Farmasierra Brand of Gemfibrozil; Faulding Brand of Gemfibrozil;Ferrer Brand of Gemfibrozil; Gemfibrozilo Bayvit; Gemfibrozilo Bexal; Gemfibrozilo Ur; Gen Gemfibrozil; GenRX Gemfibrozil; Genpharm Brand of Gemfibrozil; Gevilon Uno; Healthsense Brand of Gemfibrozil; Healthsense Gemfibrozil; Hexal Brand of Gemfibrozil; Ipsen Brand of Gemfibrozil; Lipox Gemfi; Lopid R; Menarini Brand of Gemfibrozil; Novo Gemfibrozil; Novopharm Brand of Gemfibrozil; Nu Gemfibrozil; Nu Pharm Brand of Gemfibrozil; PMS Gemfibrozil; Parke Davis Brand of Gemfibrozil; Pfizer Brand of Gemfibrozil; Pharmascience Brand of Gemfibrozil; Quimifar Brand of Gemfibrozil; SBPA Gemfibrozil; Sigma Brand of Gemfibrozil; TAD Brand of Gemfibrozil; Terry White Chemists Brand of Gemfibrozil; Terry White Chemists Gemfibrozil; United Drug Brand of Gemfibrozil; Warner Lambert Brand of Gemfibrozil; CI719; Gemfi 1A Pharma; Apo-Gemfibrozil; Bayvit, Gemfibrozilo; Gem-S; Gemfibrozil, GenRX; Gemfibrozil, Healthsense; Gemfibrozil, SBPA; Gemfibrozilo [INN-Spanish]; Gemfibrozilum [INN-Latin]; Gen-Fibro;Gen-Gemfibrozil; Jezil (TN); Lopid (TN); Low-Lip; Novo-Gemfibrozil; Nu-Gemfibrozil; Nu-Pharm Brand of Gemfibrozil; PMS-Gemfibrozil; TEVA-A; WL-Gemfibrozil; Warner-Lambert Brand of Gemfibrozil; GEMFIBROZIL (SEE ALSO PEROXISOME PROJECT (GEMFIBROZIL)); Gemfibrozil [USAN:BAN:INN]; Gen-Fibro (TN); PEROXISOME PROJECT (GEMFIBROZIL) (SEE ALSO GEMFIBROZIL); Gemfibrozil (JAN/USP/INN); Gemcor, Lopid, Jezil,Gen-Fibro, Gemfibrozil; 1A Brand of Gemfibrozil; 2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid; 2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure; 2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure; 2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid; 5-(2,5-Dimethyl-Phenoxy)-2,2-Dimethyl-Pentanoic Acid; 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid; 5-[(2,5-dimethylphenyl)oxy]-2,2-dimethylpentanoic acid Click to Show/Hide
Disease Class	5C80: Hyper-lipoproteinaemia
Therapeutic Class	Antihyperammonia Agents
Structure
Structure	3D Structure		2D Structure
Formula	C15H22O3
InChI	1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)
InChIKey	HEMJJKBWTPKOJG-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=C(C=C1)C)OCCCC(C)(C)C(=O)O
External Link
	Pubchem ID	3463
	CAS Number	25812-30-0
	CHEBI ID	5296
	TTD ID	D05VIX
	INTEDE ID	DR0766
	VARIDT ID	DR00540

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM008 Altered Fat-soluble drugs absorption BM010 Transporter inhibition BM013 Competitive binding of plasma proteins BM017 CYP450 enzyme inhibition BM019 UGT inhibition BM023 UGT induction BM025 Decreased metabolism (Unspecific) BM055 Increased risk of hepatotoxicity BM064 Increased risk of hypoglycemia BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Gemfibrozil
Affected gastrointestinal absorption
	Altered Fat-soluble drugs absorption					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0381		Colesevelam	C31H67Cl3N4O	160051	Moderate		Inter Info	[3], [25], [4], [163], [43]
D0382		Colestipol	C11H28ClN5O	62816	Moderate		Inter Info	[3], [25], [4], [163], [43]
D0329		Cholestyramine	C27H47ClN2	137699107	Moderate		Inter Info	[3], [25], [4], [163], [43]
Affected cellular transport
	Transporter inhibition					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0555		Elagolix	C32H30F5N3O5	11250647	Major		Inter Info	[19]
D0562		Eluxadoline	C32H35N5O5	11250029	Major		Inter Info	[4], [20], [21]
D0739		Grazoprevir	C38H50N6O9S	44603531	Major		Inter Info	[4], [23], [24]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Major		Inter Info	[60], [61]
D1396		Revefenacin	C35H43N5O4	11753673	Moderate		Inter Info	[185], [23], [186]
D1710		Voxilaprevir	C40H52F4N6O9S	89921642	Moderate		Inter Info	[190]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9]
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[3], [4], [7]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 33
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0427		Dasabuvir	C26H27N3O5S	56640146	Major		Inter Info	[16], [17], [18]
D0590		Erdafitinib	C25H30N6O2	67462786	Major		Inter Info	[22]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[25], [26]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[27]
D1457		Selexipag	C26H32N4O4S	9913767	Major		Inter Info	[30], [31], [32]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[25], [33]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[34]
D0947		Loperamide	C29H33ClN2O2	3955	Major		Inter Info	[37], [38], [39], [40], [41], [42]
D1294		Pioglitazone	C19H20N2O3S	4829	Major		Inter Info	[46], [47], [48], [49], [16], [50], [51], [52]
D1392		Repaglinide	C27H36N2O4	65981	Major		Inter Info	[53], [54], [55], [56], [57], [58], [59]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[162]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[25]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[25], [4], [164]
D0130		Avatrombopag	C29H34Cl2N6O3S2	9852519	Moderate		Inter Info	[4]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[25], [4], [165]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[25], [167], [168]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[169]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[170]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[25]
D0885		Lacosamide	C13H18N2O3	219078	Moderate		Inter Info	[25], [4], [178]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[179]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[180]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[4], [183], [184]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[191], [192]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[134], [193]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[194], [195], [25], [196], [197], [198], [199], [200]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[194], [195], [25]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[201]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[202], [203], [204], [51]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[205], [206], [207]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[208]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[209], [210]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Minor		Inter Info	[211]
	UGT inhibition					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1435		Sacituzumab govitecan	C76H104N12O24S	91668186	Major		Inter Info	[28], [29]
D0845		Irinotecan	C33H38N4O6	60838	Major		Inter Info	[25], [4], [35], [36]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Major		Inter Info	[25], [4], [36]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[25], [4], [166]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[182]
	UGT induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[25], [4], [181]
	Decreased metabolism (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0178		Bexarotene	C24H28O2	82146	Major		Inter Info	[13], [14], [15]
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[4], [189]
	Increased risk of hypoglycemia					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [43], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [58], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [43], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [58], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[70], [126], [142]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[70], [126], [142]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [171], [74], [75], [76], [77], [78], [79], [80], [81], [83], [84], [85], [87], [88], [89], [90], [92], [93], [94], [96], [98], [99], [100], [101], [102], [103], [104], [105], [106], [108], [110], [112], [113], [114], [117], [118], [120], [121], [122], [124], [172], [126], [173], [174], [131], [175], [176], [136], [138], [139], [140], [142], [144], [146], [148], [149], [153], [154], [155], [156], [177], [157], [158], [160], [161]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [171], [74], [75], [76], [77], [78], [79], [80], [81], [83], [84], [85], [87], [88], [89], [90], [92], [93], [94], [96], [98], [99], [100], [101], [102], [103], [104], [105], [106], [108], [110], [112], [113], [114], [117], [118], [120], [121], [122], [124], [172], [126], [173], [174], [131], [175], [176], [136], [138], [139], [140], [142], [144], [146], [148], [149], [153], [154], [155], [156], [177], [157], [158], [160], [161]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [171], [74], [75], [76], [77], [78], [79], [80], [81], [83], [84], [85], [87], [88], [89], [90], [92], [93], [94], [96], [98], [99], [100], [101], [102], [103], [104], [105], [106], [108], [110], [112], [113], [114], [117], [118], [120], [121], [122], [124], [172], [126], [173], [174], [131], [175], [176], [136], [138], [139], [140], [142], [144], [146], [148], [149], [153], [154], [155], [156], [177], [157], [158], [160], [161]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [43], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [58], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [43], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [58], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [43], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [58], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [171], [74], [75], [76], [77], [78], [79], [80], [81], [83], [84], [85], [87], [88], [89], [90], [92], [93], [94], [96], [98], [99], [100], [101], [102], [103], [104], [105], [106], [108], [110], [112], [113], [114], [117], [118], [120], [121], [122], [124], [172], [126], [173], [174], [131], [175], [176], [136], [138], [139], [140], [142], [144], [146], [148], [149], [153], [154], [155], [156], [177], [157], [158], [160], [161]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[70], [126], [142]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[70], [126], [142]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[70], [126], [142]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[70], [126], [142]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[70], [126], [142]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[70], [126], [142]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [171], [74], [75], [76], [77], [78], [79], [80], [81], [83], [84], [85], [87], [88], [89], [90], [92], [93], [94], [96], [98], [99], [100], [101], [102], [103], [104], [105], [106], [108], [110], [112], [113], [114], [117], [118], [120], [121], [122], [124], [172], [126], [173], [174], [131], [175], [176], [136], [138], [139], [140], [142], [144], [146], [148], [149], [153], [154], [155], [156], [177], [157], [158], [160], [161]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[70], [126], [142]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [43], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [58], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0120		Atorvastatin	C33H35FN2O5	60823	Major		Inter Info	[10], [11], [12]
D0303		Cerivastatin	C26H34FNO5	446156	Major		Inter Info	[10], [11], [12]
D0686		Fluvastatin	C24H26FNO4	446155	Major		Inter Info	[10], [11], [12]
D1301		Pitavastatin	C25H24FNO4	5282452	Major		Inter Info	[10], [11], [12]
D0956		Lovastatin	C24H36O5	53232	Major		Inter Info	[43], [44], [45]
D1329		Pravastatin	C23H36O7	54687	Major		Inter Info	[10], [11], [12]
D1473		Simvastatin	C25H38O5	54454	Major		Inter Info	[11], [12], [62]
D0421		Daptomycin	C72H101N17O26	16134395	Moderate		Inter Info	[4]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[187], [188]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[187], [188]

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